7T2G
CryoEM structure of mu-opioid receptor - Gi protein complex bound to mitragynine pseudoindoxyl (MP)
Summary for 7T2G
Entry DOI | 10.2210/pdb7t2g/pdb |
EMDB information | 25612 |
Descriptor | Guanine nucleotide-binding protein G(i) subunit alpha-1, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... (7 entities in total) |
Functional Keywords | gpcr, mu-opioid receptor, lofentanil (lft), mitragynine pseudoindoxyl (mp), membrane protein |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 4 |
Total formula weight | 142258.90 |
Authors | Seven, A.B.,Qu, Q.,Robertson, M.J.,Wang, H.,Kobilka, B.K.,Skiniotis, G. (deposition date: 2021-12-04, release date: 2022-12-07, Last modification date: 2023-02-15) |
Primary citation | Qu, Q.,Huang, W.,Aydin, D.,Paggi, J.M.,Seven, A.B.,Wang, H.,Chakraborty, S.,Che, T.,DiBerto, J.F.,Robertson, M.J.,Inoue, A.,Suomivuori, C.M.,Roth, B.L.,Majumdar, S.,Dror, R.O.,Kobilka, B.K.,Skiniotis, G. Insights into distinct signaling profiles of the mu OR activated by diverse agonists. Nat.Chem.Biol., 2022 Cited by PubMed: 36411392DOI: 10.1038/s41589-022-01208-y PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (2.5 Å) |
Structure validation
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