7SZR
NIK bound to inhibitor G02792917
Summary for 7SZR
Entry DOI | 10.2210/pdb7szr/pdb |
Descriptor | Mitogen-activated protein kinase kinase kinase 14, SULFATE ION, 1-(3-{[(1R,4R,5S)-4-hydroxy-2-methyl-3-oxo-2-azabicyclo[3.1.0]hexan-4-yl]ethynyl}phenyl)-1H-pyrazolo[3,4-b]pyridine-3-carboxamide (3 entities in total) |
Functional Keywords | kinase, inhibitor, nf-kb inducing kinase, signaling protein |
Biological source | Mus musculus (house mouse) |
Total number of polymer chains | 2 |
Total formula weight | 78954.52 |
Authors | Liau, N.P.D.,Hymowitz, S.G. (deposition date: 2021-11-29, release date: 2023-06-07, Last modification date: 2023-12-20) |
Primary citation | Crawford, J.J.,Feng, J.,Brightbill, H.D.,Johnson, A.R.,Wright, M.,Kolesnikov, A.,Lee, W.,Castanedo, G.M.,Do, S.,Blaquiere, N.,Staben, S.T.,Chiang, P.C.,Fan, P.W.,Baumgardner, M.,Wong, S.,Godemann, R.,Grabbe, A.,Wiegel, C.,Sujatha-Bhaskar, S.,Hymowitz, S.G.,Liau, N.,Hsu, P.L.,McEwan, P.A.,Ismaili, M.H.A.,Landry, M.L. Filling a nick in NIK: Extending the half-life of a NIK inhibitor through structure-based drug design. Bioorg.Med.Chem.Lett., 89:129277-129277, 2023 Cited by PubMed: 37105490DOI: 10.1016/j.bmcl.2023.129277 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.8 Å) |
Structure validation
Download full validation report