7SHT
Structure of a partially disrupted IgE high affinity receptor complex bound to an omalizumab variant
Summary for 7SHT
Entry DOI | 10.2210/pdb7sht/pdb |
EMDB information | 25136 |
Descriptor | High affinity immunoglobulin epsilon receptor subunit alpha, Immunoglobulin heavy constant epsilon, clone_7 Variable fragment heavy chain, ... (8 entities in total) |
Functional Keywords | ige, allergy, xolair, omalizumab, immune system |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 7 |
Total formula weight | 153771.69 |
Authors | |
Primary citation | Pennington, L.F.,Gasser, P.,Kleinboelting, S.,Zhang, C.,Skiniotis, G.,Eggel, A.,Jardetzky, T.S. Directed evolution of and structural insights into antibody-mediated disruption of a stable receptor-ligand complex. Nat Commun, 12:7069-7069, 2021 Cited by PubMed: 34862384DOI: 10.1038/s41467-021-27397-z PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (7.29 Å) |
Structure validation
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