7SGM
Crystal structure of a Fab variant containing a fluorescent noncanonical amino acid with blocked excited state proton transfer and in complex with its antigen, CD40L
Summary for 7SGM
Entry DOI | 10.2210/pdb7sgm/pdb |
Descriptor | CD40 ligand, 5c8* Fab heavy chain, 5c8* Fab light chain, ... (8 entities in total) |
Functional Keywords | fragment antigen binding (fab), noncanonical amino acid, 7-hydroxycoumarin, immune system, cytokine-immune system complex, cytokine/immune system |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 9 |
Total formula weight | 193887.32 |
Authors | Henderson, J.N.,Mills, J.H.,Simmons, C.R. (deposition date: 2021-10-06, release date: 2022-02-02, Last modification date: 2023-11-15) |
Primary citation | Henderson, J.N.,Simmons, C.R.,Mills, J.H. Structural Basis for Blocked Excited State Proton Transfer in a Fluorescent, Photoacidic Non-Canonical Amino Acid-Containing Antibody Fragment. J.Mol.Biol., 434:167455-167455, 2022 Cited by PubMed: 35033559DOI: 10.1016/j.jmb.2022.167455 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2 Å) |
Structure validation
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