7S83

Crystal structure of SARS CoV-2 Spike Receptor Binding Domain in complex with shark neutralizing VNARs ShAb01 and ShAb02

Summary for 7S83

• Entry DOI: 10.2210/pdb7s83/pdb
• Descriptor: ShAb02 VNAR, Spike protein S1, ShAb01 VNAR, ... (6 entities in total)
• Functional Keywords: shark antibody, ignar, vnar, sars cov-2, spike protein, receptor binding domain, immune system, immune system-viral protein complex, immune system/viral protein
• Biological source: Ginglymostoma cirratum (nurse shark); More
• Total number of polymer chains: 3
• Total formula weight: 52834.38

Authors

Chen, W.-H.,Hajduczki, A.,Dooley, H.M.,Joyce, M.G. (deposition date: 2021-09-17, release date: 2022-11-23, Last modification date: 2023-10-25)

• Primary citation: Chen, W.H.,Hajduczki, A.,Martinez, E.J.,Bai, H.,Matz, H.,Hill, T.M.,Lewitus, E.,Chang, W.C.,Dawit, L.,Peterson, C.E.,Rees, P.A.,Ajayi, A.B.,Golub, E.S.,Swafford, I.,Dussupt, V.,David, S.,Mayer, S.V.,Soman, S.,Kuklis, C.,Corbitt, C.,King, J.,Choe, M.,Sankhala, R.S.,Thomas, P.V.,Zemil, M.,Wieczorek, L.,Hart, T.,Duso, D.,Kummer, L.,Yan, L.,Sterling, S.L.,Laing, E.D.,Broder, C.C.,Williams, J.K.,Davidson, E.,Doranz, B.J.,Krebs, S.J.,Polonis, V.R.,Paquin-Proulx, D.,Rolland, M.,Reiley, W.W.,Gromowski, G.D.,Modjarrad, K.,Dooley, H.,Joyce, M.G.; Shark nanobodies with potent SARS-CoV-2 neutralizing activity and broad sarbecovirus reactivity.; Nat Commun, 14:580-580, 2023; PubMed: 36737435; DOI: 10.1038/s41467-023-36106-x

Experimental method

X-RAY DIFFRACTION (2.52 Å)