7S83
Crystal structure of SARS CoV-2 Spike Receptor Binding Domain in complex with shark neutralizing VNARs ShAb01 and ShAb02
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (B) | ShAb02 VNAR | polymer | 128 | 14343.7 | 1 | Ginglymostoma cirratum (nurse shark) | ||
| 2 | B (C) | Spike protein S1 | polymer | 205 | 23073.8 | 1 | UniProt (P0DTC2) Pfam (PF09408) | Severe acute respiratory syndrome coronavirus 2 (2019-nCoV SARS-CoV-2) | |
| 3 | C (A) | ShAb01 VNAR | polymer | 131 | 14900.4 | 1 | Ginglymostoma cirratum (nurse shark) | ||
| 4 | D (D) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 1 | In PDB GlyTouCan (G42666HT) | |||
| 5 | E (C) | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) | |||
| 6 | F, G, H (B, C, A) | water | water | 18.0 | 45 | Chemie (HOH) |
Sequence modifications
C: 331 - 527 (UniProt: P0DTC2)
| PDB | External Database | Details |
|---|---|---|
| Gly 528 | - | expression tag |
| Ser 529 | - | expression tag |
| His 530 | - | expression tag |
| His 531 | - | expression tag |
| His 532 | - | expression tag |
| His 533 | - | expression tag |
| His 534 | - | expression tag |
| His 535 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 52317.9 | |
| Branched | Number of molecules | 1 |
| Total formula weight | 424.4 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 92.1 | |
| All* | Total formula weight | 52834.4 |
