7RCT
Non-receptor Protein Tyrosine Phosphatase SHP2 in Complex with Allosteric Inhibitor RMC-4550
Summary for 7RCT
Entry DOI | 10.2210/pdb7rct/pdb |
Descriptor | Tyrosine-protein phosphatase non-receptor type 11, {3-[(3S,4S)-4-amino-3-methyl-2-oxa-8-azaspiro[4.5]decan-8-yl]-6-(2,3-dichlorophenyl)-5-methylpyrazin-2-yl}methanol, CHLORIDE ION, ... (4 entities in total) |
Functional Keywords | shp2 rmc-4550 phosphatase, signaling protein |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 2 |
Total formula weight | 121441.55 |
Authors | Seegar, T.C.M. (deposition date: 2021-07-08, release date: 2021-09-01, Last modification date: 2024-10-09) |
Primary citation | Vemulapalli, V.,Donovan, K.A.,Seegar, T.C.M.,Rogers, J.M.,Bae, M.,Lumpkin, R.J.,Cao, R.,Henke, M.T.,Ray, S.S.,Fischer, E.S.,Cuny, G.D.,Blacklow, S.C. Targeted Degradation of the Oncogenic Phosphatase SHP2. Biochemistry, 60:2593-2609, 2021 Cited by PubMed: 34411482DOI: 10.1021/acs.biochem.1c00377 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.8 Å) |
Structure validation
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