7QI8
CRYSTAL STRUCTURE OF LYSYL-TRNA SYNTHETASE FROM Mycobacterium tuberculosis COMPLEXED WITH L-LYSINE AND INHIBITOR
Summary for 7QI8
Entry DOI | 10.2210/pdb7qi8/pdb |
Related | 7QH8 7QHN |
Descriptor | Lysine--tRNA ligase 1, LYSINE, 2-azanyl-6-[(1~{S},7~{S})-2,2-bis(fluoranyl)-7-oxidanyl-cycloheptyl]-4-methoxy-7~{H}-pyrrolo[3,4-d]pyrimidin-5-one, ... (4 entities in total) |
Functional Keywords | ligase, mycobacterium tuberculosis, atp binding |
Biological source | Mycobacterium tuberculosis H37Rv |
Total number of polymer chains | 1 |
Total formula weight | 58605.08 |
Authors | Dawson, A.,Robinson, D.A.,Tamjar, J.,Wyatt, P.,Green, S. (deposition date: 2021-12-14, release date: 2022-10-19, Last modification date: 2024-02-07) |
Primary citation | Green, S.R.,Davis, S.H.,Damerow, S.,Engelhart, C.A.,Mathieson, M.,Baragana, B.,Robinson, D.A.,Tamjar, J.,Dawson, A.,Tamaki, F.K.,Buchanan, K.I.,Post, J.,Dowers, K.,Shepherd, S.M.,Jansen, C.,Zuccotto, F.,Gilbert, I.H.,Epemolu, O.,Riley, J.,Stojanovski, L.,Osuna-Cabello, M.,Perez-Herran, E.,Rebollo, M.J.,Guijarro Lopez, L.,Casado Castro, P.,Camino, I.,Kim, H.C.,Bean, J.M.,Nahiyaan, N.,Rhee, K.Y.,Wang, Q.,Tan, V.Y.,Boshoff, H.I.M.,Converse, P.J.,Li, S.Y.,Chang, Y.S.,Fotouhi, N.,Upton, A.M.,Nuermberger, E.L.,Schnappinger, D.,Read, K.D.,Encinas, L.,Bates, R.H.,Wyatt, P.G.,Cleghorn, L.A.T. Lysyl-tRNA synthetase, a target for urgently needed M. tuberculosis drugs. Nat Commun, 13:5992-5992, 2022 Cited by PubMed: 36220877DOI: 10.1038/s41467-022-33736-5 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.2 Å) |
Structure validation
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