7QI8
CRYSTAL STRUCTURE OF LYSYL-TRNA SYNTHETASE FROM Mycobacterium tuberculosis COMPLEXED WITH L-LYSINE AND INHIBITOR
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Lysine--tRNA ligase 1 | polymer | 526 | 58129.6 | 1 | UniProt (P9WFU9) Pfam (PF01336) Pfam (PF00152) In PDB | Mycobacterium tuberculosis H37Rv | Lysyl-tRNA synthetase 1,LysRS 1 |
2 | A | LYSINE | non-polymer | 147.2 | 1 | Chemie (LYS) | |||
3 | A | 2-azanyl-6-[(1~{S},7~{S})-2,2-bis(fluoranyl)-7-oxidanyl-cycloheptyl]-4-methoxy-7~{H}-pyrrolo[3,4-d]pyrimidin-5-one | non-polymer | 328.3 | 1 | Chemie (DD0) | |||
4 | water | water | 18.0 | 69 | Chemie (HOH) |
Sequence modifications
A: 1 - 505 (UniProt: P9WFU9)
PDB | External Database | Details |
---|---|---|
Met -20 | - | initiating methionine |
Gly -19 | - | expression tag |
Ser -18 | - | expression tag |
Ser -17 | - | expression tag |
His -16 | - | expression tag |
His -15 | - | expression tag |
His -14 | - | expression tag |
His -13 | - | expression tag |
His -12 | - | expression tag |
His -11 | - | expression tag |
Ser -10 | - | expression tag |
Ser -9 | - | expression tag |
Gly -8 | - | expression tag |
Glu -7 | - | expression tag |
Asn -6 | - | expression tag |
Leu -5 | - | expression tag |
Tyr -4 | - | expression tag |
Phe -3 | - | expression tag |
Gln -2 | - | expression tag |
Gly -1 | - | expression tag |
His 0 | - | expression tag |
Ala 455 | Met 455 | conflict |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 1 |
Total formula weight | 58129.6 | |
Non-Polymers* | Number of molecules | 2 |
Total formula weight | 475.5 | |
All* | Total formula weight | 58605.1 |