7PZC
Cryo-EM structure of the NLRP3 decamer bound to the inhibitor CRID3
Summary for 7PZC
Entry DOI | 10.2210/pdb7pzc/pdb |
EMDB information | 13684 13685 13686 13692 13693 13699 |
Descriptor | NACHT, LRR and PYD domains-containing protein 3, ADENOSINE-5'-DIPHOSPHATE, 1-(1,2,3,5,6,7-hexahydro-s-indacen-4-yl)-3-[4-(2-oxidanylpropan-2-yl)furan-2-yl]sulfonyl-urea (3 entities in total) |
Functional Keywords | nlrp3, cp-456.773, crid3, mcc950, aaa+ atpase, nod-like receptor, inflammasome, immune system |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 10 |
Total formula weight | 1191552.12 |
Authors | Hochheiser, I.V.,Pilsl, M.,Hagelueken, G.,Engel, C.,Geyer, M. (deposition date: 2021-10-12, release date: 2022-01-26, Last modification date: 2024-07-17) |
Primary citation | Hochheiser, I.V.,Pilsl, M.,Hagelueken, G.,Moecking, J.,Marleaux, M.,Brinkschulte, R.,Latz, E.,Engel, C.,Geyer, M. Structure of the NLRP3 decamer bound to the cytokine release inhibitor CRID3. Nature, 604:184-189, 2022 Cited by PubMed: 35114687DOI: 10.1038/s41586-022-04467-w PDB entries with the same primary citation |
Experimental method |
Structure validation
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