7PZC
Cryo-EM structure of the NLRP3 decamer bound to the inhibitor CRID3
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D, E... (A, B, C, D, E...) | NACHT, LRR and PYD domains-containing protein 3 | polymer | 1036 | 118323.5 | 10 | UniProt (Q96P20) Pfam (PF02758) Pfam (PF14484) Pfam (PF05729) Pfam (PF17779) Pfam (PF17776) Pfam (PF13516) | Homo sapiens (human) | Angiotensin/vasopressin receptor AII/AVP-like,Caterpiller protein 1.1,CLR1.1,Cold-induced autoinflammatory syndrome 1 protein,Cryopyrin,PYRIN-containing APAF1-like protein 1 |
| 2 | AA, CA, K, M, O... (I, J, A, B, C...) | ADENOSINE-5'-DIPHOSPHATE | non-polymer | 427.2 | 10 | Chemie (ADP) | |||
| 3 | BA, DA, L, N, P... (I, J, A, B, C...) | 1-(1,2,3,5,6,7-hexahydro-s-indacen-4-yl)-3-[4-(2-oxidanylpropan-2-yl)furan-2-yl]sulfonyl-urea | non-polymer | 404.5 | 10 | Chemie (8GI) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 10 |
| Total formula weight | 1183235.3 | |
| Non-Polymers* | Number of molecules | 20 |
| Total formula weight | 8316.8 | |
| All* | Total formula weight | 1191552.1 |
