7PZC

Cryo-EM structure of the NLRP3 decamer bound to the inhibitor CRID3

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000139	cellular_component	Golgi membrane
A	0000166	molecular_function	nucleotide binding
A	0002221	biological_process	pattern recognition receptor signaling pathway
A	0002376	biological_process	immune system process
A	0002674	biological_process	negative regulation of acute inflammatory response
A	0002830	biological_process	positive regulation of type 2 immune response
A	0005515	molecular_function	protein binding
A	0005524	molecular_function	ATP binding
A	0005576	cellular_component	extracellular region
A	0005634	cellular_component	nucleus
A	0005737	cellular_component	cytoplasm
A	0005739	cellular_component	mitochondrion
A	0005783	cellular_component	endoplasmic reticulum
A	0005815	cellular_component	microtubule organizing center
A	0005829	cellular_component	cytosol
A	0006355	biological_process	regulation of DNA-templated transcription
A	0006915	biological_process	apoptotic process
A	0006952	biological_process	defense response
A	0006954	biological_process	inflammatory response
A	0007165	biological_process	signal transduction
A	0007231	biological_process	osmosensory signaling pathway
A	0009595	biological_process	detection of biotic stimulus
A	0009615	biological_process	response to virus
A	0016020	cellular_component	membrane
A	0016787	molecular_function	hydrolase activity
A	0016887	molecular_function	ATP hydrolysis activity
A	0030674	molecular_function	protein-macromolecule adaptor activity
A	0031021	cellular_component	interphase microtubule organizing center
A	0032691	biological_process	negative regulation of interleukin-1 beta production
A	0032731	biological_process	positive regulation of interleukin-1 beta production
A	0032753	biological_process	positive regulation of interleukin-4 production
A	0035591	molecular_function	signaling adaptor activity
A	0042802	molecular_function	identical protein binding
A	0042834	molecular_function	peptidoglycan binding
A	0043531	molecular_function	ADP binding
A	0043565	molecular_function	sequence-specific DNA binding
A	0044546	biological_process	NLRP3 inflammasome complex assembly
A	0045087	biological_process	innate immune response
A	0045630	biological_process	positive regulation of T-helper 2 cell differentiation
A	0045944	biological_process	positive regulation of transcription by RNA polymerase II
A	0050727	biological_process	regulation of inflammatory response
A	0050728	biological_process	negative regulation of inflammatory response
A	0050729	biological_process	positive regulation of inflammatory response
A	0051092	biological_process	positive regulation of NF-kappaB transcription factor activity
A	0051260	biological_process	protein homooligomerization
A	0051604	biological_process	protein maturation
A	0060090	molecular_function	molecular adaptor activity
A	0061702	cellular_component	canonical inflammasome complex
A	0070269	biological_process	pyroptotic inflammatory response
A	0070273	molecular_function	phosphatidylinositol-4-phosphate binding
A	0071222	biological_process	cellular response to lipopolysaccharide
A	0072559	cellular_component	NLRP3 inflammasome complex
A	0098586	biological_process	cellular response to virus
A	0140297	molecular_function	DNA-binding transcription factor binding
A	0140299	molecular_function	molecular sensor activity
A	0140608	molecular_function	cysteine-type endopeptidase activator activity
A	0140693	molecular_function	molecular condensate scaffold activity
A	1901223	biological_process	negative regulation of non-canonical NF-kappaB signal transduction
A	1901224	biological_process	positive regulation of non-canonical NF-kappaB signal transduction
A	1901981	molecular_function	phosphatidylinositol phosphate binding
A	2000553	biological_process	positive regulation of T-helper 2 cell cytokine production
B	0000139	cellular_component	Golgi membrane
B	0000166	molecular_function	nucleotide binding
B	0002221	biological_process	pattern recognition receptor signaling pathway
B	0002376	biological_process	immune system process
B	0002674	biological_process	negative regulation of acute inflammatory response
B	0002830	biological_process	positive regulation of type 2 immune response
B	0005515	molecular_function	protein binding
B	0005524	molecular_function	ATP binding
B	0005576	cellular_component	extracellular region
B	0005634	cellular_component	nucleus
B	0005737	cellular_component	cytoplasm
B	0005739	cellular_component	mitochondrion
B	0005783	cellular_component	endoplasmic reticulum
B	0005815	cellular_component	microtubule organizing center
B	0005829	cellular_component	cytosol
B	0006355	biological_process	regulation of DNA-templated transcription
B	0006915	biological_process	apoptotic process
B	0006952	biological_process	defense response
B	0006954	biological_process	inflammatory response
B	0007165	biological_process	signal transduction
B	0007231	biological_process	osmosensory signaling pathway
B	0009595	biological_process	detection of biotic stimulus
B	0009615	biological_process	response to virus
B	0016020	cellular_component	membrane
B	0016787	molecular_function	hydrolase activity
B	0016887	molecular_function	ATP hydrolysis activity
B	0030674	molecular_function	protein-macromolecule adaptor activity
B	0031021	cellular_component	interphase microtubule organizing center
B	0032691	biological_process	negative regulation of interleukin-1 beta production
B	0032731	biological_process	positive regulation of interleukin-1 beta production
B	0032753	biological_process	positive regulation of interleukin-4 production
B	0035591	molecular_function	signaling adaptor activity
B	0042802	molecular_function	identical protein binding
B	0042834	molecular_function	peptidoglycan binding
B	0043531	molecular_function	ADP binding
B	0043565	molecular_function	sequence-specific DNA binding
B	0044546	biological_process	NLRP3 inflammasome complex assembly
B	0045087	biological_process	innate immune response
B	0045630	biological_process	positive regulation of T-helper 2 cell differentiation
B	0045944	biological_process	positive regulation of transcription by RNA polymerase II
B	0050727	biological_process	regulation of inflammatory response
B	0050728	biological_process	negative regulation of inflammatory response
B	0050729	biological_process	positive regulation of inflammatory response
B	0051092	biological_process	positive regulation of NF-kappaB transcription factor activity
B	0051260	biological_process	protein homooligomerization
B	0051604	biological_process	protein maturation
B	0060090	molecular_function	molecular adaptor activity
B	0061702	cellular_component	canonical inflammasome complex
B	0070269	biological_process	pyroptotic inflammatory response
B	0070273	molecular_function	phosphatidylinositol-4-phosphate binding
B	0071222	biological_process	cellular response to lipopolysaccharide
B	0072559	cellular_component	NLRP3 inflammasome complex
B	0098586	biological_process	cellular response to virus
B	0140297	molecular_function	DNA-binding transcription factor binding
B	0140299	molecular_function	molecular sensor activity
B	0140608	molecular_function	cysteine-type endopeptidase activator activity
B	0140693	molecular_function	molecular condensate scaffold activity
B	1901223	biological_process	negative regulation of non-canonical NF-kappaB signal transduction
B	1901224	biological_process	positive regulation of non-canonical NF-kappaB signal transduction
B	1901981	molecular_function	phosphatidylinositol phosphate binding
B	2000553	biological_process	positive regulation of T-helper 2 cell cytokine production
C	0000139	cellular_component	Golgi membrane
C	0000166	molecular_function	nucleotide binding
C	0002221	biological_process	pattern recognition receptor signaling pathway
C	0002376	biological_process	immune system process
C	0002674	biological_process	negative regulation of acute inflammatory response
C	0002830	biological_process	positive regulation of type 2 immune response
C	0005515	molecular_function	protein binding
C	0005524	molecular_function	ATP binding
C	0005576	cellular_component	extracellular region
C	0005634	cellular_component	nucleus
C	0005737	cellular_component	cytoplasm
C	0005739	cellular_component	mitochondrion
C	0005783	cellular_component	endoplasmic reticulum
C	0005815	cellular_component	microtubule organizing center
C	0005829	cellular_component	cytosol
C	0006355	biological_process	regulation of DNA-templated transcription
C	0006915	biological_process	apoptotic process
C	0006952	biological_process	defense response
C	0006954	biological_process	inflammatory response
C	0007165	biological_process	signal transduction
C	0007231	biological_process	osmosensory signaling pathway
C	0009595	biological_process	detection of biotic stimulus
C	0009615	biological_process	response to virus
C	0016020	cellular_component	membrane
C	0016787	molecular_function	hydrolase activity
C	0016887	molecular_function	ATP hydrolysis activity
C	0030674	molecular_function	protein-macromolecule adaptor activity
C	0031021	cellular_component	interphase microtubule organizing center
C	0032691	biological_process	negative regulation of interleukin-1 beta production
C	0032731	biological_process	positive regulation of interleukin-1 beta production
C	0032753	biological_process	positive regulation of interleukin-4 production
C	0035591	molecular_function	signaling adaptor activity
C	0042802	molecular_function	identical protein binding
C	0042834	molecular_function	peptidoglycan binding
C	0043531	molecular_function	ADP binding
C	0043565	molecular_function	sequence-specific DNA binding
C	0044546	biological_process	NLRP3 inflammasome complex assembly
C	0045087	biological_process	innate immune response
C	0045630	biological_process	positive regulation of T-helper 2 cell differentiation
C	0045944	biological_process	positive regulation of transcription by RNA polymerase II
C	0050727	biological_process	regulation of inflammatory response
C	0050728	biological_process	negative regulation of inflammatory response
C	0050729	biological_process	positive regulation of inflammatory response
C	0051092	biological_process	positive regulation of NF-kappaB transcription factor activity
C	0051260	biological_process	protein homooligomerization
C	0051604	biological_process	protein maturation
C	0060090	molecular_function	molecular adaptor activity
C	0061702	cellular_component	canonical inflammasome complex
C	0070269	biological_process	pyroptotic inflammatory response
C	0070273	molecular_function	phosphatidylinositol-4-phosphate binding
C	0071222	biological_process	cellular response to lipopolysaccharide
C	0072559	cellular_component	NLRP3 inflammasome complex
C	0098586	biological_process	cellular response to virus
C	0140297	molecular_function	DNA-binding transcription factor binding
C	0140299	molecular_function	molecular sensor activity
C	0140608	molecular_function	cysteine-type endopeptidase activator activity
C	0140693	molecular_function	molecular condensate scaffold activity
C	1901223	biological_process	negative regulation of non-canonical NF-kappaB signal transduction
C	1901224	biological_process	positive regulation of non-canonical NF-kappaB signal transduction
C	1901981	molecular_function	phosphatidylinositol phosphate binding
C	2000553	biological_process	positive regulation of T-helper 2 cell cytokine production
D	0000139	cellular_component	Golgi membrane
D	0000166	molecular_function	nucleotide binding
D	0002221	biological_process	pattern recognition receptor signaling pathway
D	0002376	biological_process	immune system process
D	0002674	biological_process	negative regulation of acute inflammatory response
D	0002830	biological_process	positive regulation of type 2 immune response
D	0005515	molecular_function	protein binding
D	0005524	molecular_function	ATP binding
D	0005576	cellular_component	extracellular region
D	0005634	cellular_component	nucleus
D	0005737	cellular_component	cytoplasm
D	0005739	cellular_component	mitochondrion
D	0005783	cellular_component	endoplasmic reticulum
D	0005815	cellular_component	microtubule organizing center
D	0005829	cellular_component	cytosol
D	0006355	biological_process	regulation of DNA-templated transcription
D	0006915	biological_process	apoptotic process
D	0006952	biological_process	defense response
D	0006954	biological_process	inflammatory response
D	0007165	biological_process	signal transduction
D	0007231	biological_process	osmosensory signaling pathway
D	0009595	biological_process	detection of biotic stimulus
D	0009615	biological_process	response to virus
D	0016020	cellular_component	membrane
D	0016787	molecular_function	hydrolase activity
D	0016887	molecular_function	ATP hydrolysis activity
D	0030674	molecular_function	protein-macromolecule adaptor activity
D	0031021	cellular_component	interphase microtubule organizing center
D	0032691	biological_process	negative regulation of interleukin-1 beta production
D	0032731	biological_process	positive regulation of interleukin-1 beta production
D	0032753	biological_process	positive regulation of interleukin-4 production
D	0035591	molecular_function	signaling adaptor activity
D	0042802	molecular_function	identical protein binding
D	0042834	molecular_function	peptidoglycan binding
D	0043531	molecular_function	ADP binding
D	0043565	molecular_function	sequence-specific DNA binding
D	0044546	biological_process	NLRP3 inflammasome complex assembly
D	0045087	biological_process	innate immune response
D	0045630	biological_process	positive regulation of T-helper 2 cell differentiation
D	0045944	biological_process	positive regulation of transcription by RNA polymerase II
D	0050727	biological_process	regulation of inflammatory response
D	0050728	biological_process	negative regulation of inflammatory response
D	0050729	biological_process	positive regulation of inflammatory response
D	0051092	biological_process	positive regulation of NF-kappaB transcription factor activity
D	0051260	biological_process	protein homooligomerization
D	0051604	biological_process	protein maturation
D	0060090	molecular_function	molecular adaptor activity
D	0061702	cellular_component	canonical inflammasome complex
D	0070269	biological_process	pyroptotic inflammatory response
D	0070273	molecular_function	phosphatidylinositol-4-phosphate binding
D	0071222	biological_process	cellular response to lipopolysaccharide
D	0072559	cellular_component	NLRP3 inflammasome complex
D	0098586	biological_process	cellular response to virus
D	0140297	molecular_function	DNA-binding transcription factor binding
D	0140299	molecular_function	molecular sensor activity
D	0140608	molecular_function	cysteine-type endopeptidase activator activity
D	0140693	molecular_function	molecular condensate scaffold activity
D	1901223	biological_process	negative regulation of non-canonical NF-kappaB signal transduction
D	1901224	biological_process	positive regulation of non-canonical NF-kappaB signal transduction
D	1901981	molecular_function	phosphatidylinositol phosphate binding
D	2000553	biological_process	positive regulation of T-helper 2 cell cytokine production
E	0000139	cellular_component	Golgi membrane
E	0000166	molecular_function	nucleotide binding
E	0002221	biological_process	pattern recognition receptor signaling pathway
E	0002376	biological_process	immune system process
E	0002674	biological_process	negative regulation of acute inflammatory response
E	0002830	biological_process	positive regulation of type 2 immune response
E	0005515	molecular_function	protein binding
E	0005524	molecular_function	ATP binding
E	0005576	cellular_component	extracellular region
E	0005634	cellular_component	nucleus
E	0005737	cellular_component	cytoplasm
E	0005739	cellular_component	mitochondrion
E	0005783	cellular_component	endoplasmic reticulum
E	0005815	cellular_component	microtubule organizing center
E	0005829	cellular_component	cytosol
E	0006355	biological_process	regulation of DNA-templated transcription
E	0006915	biological_process	apoptotic process
E	0006952	biological_process	defense response
E	0006954	biological_process	inflammatory response
E	0007165	biological_process	signal transduction
E	0007231	biological_process	osmosensory signaling pathway
E	0009595	biological_process	detection of biotic stimulus
E	0009615	biological_process	response to virus
E	0016020	cellular_component	membrane
E	0016787	molecular_function	hydrolase activity
E	0016887	molecular_function	ATP hydrolysis activity
E	0030674	molecular_function	protein-macromolecule adaptor activity
E	0031021	cellular_component	interphase microtubule organizing center
E	0032691	biological_process	negative regulation of interleukin-1 beta production
E	0032731	biological_process	positive regulation of interleukin-1 beta production
E	0032753	biological_process	positive regulation of interleukin-4 production
E	0035591	molecular_function	signaling adaptor activity
E	0042802	molecular_function	identical protein binding
E	0042834	molecular_function	peptidoglycan binding
E	0043531	molecular_function	ADP binding
E	0043565	molecular_function	sequence-specific DNA binding
E	0044546	biological_process	NLRP3 inflammasome complex assembly
E	0045087	biological_process	innate immune response
E	0045630	biological_process	positive regulation of T-helper 2 cell differentiation
E	0045944	biological_process	positive regulation of transcription by RNA polymerase II
E	0050727	biological_process	regulation of inflammatory response
E	0050728	biological_process	negative regulation of inflammatory response
E	0050729	biological_process	positive regulation of inflammatory response
E	0051092	biological_process	positive regulation of NF-kappaB transcription factor activity
E	0051260	biological_process	protein homooligomerization
E	0051604	biological_process	protein maturation
E	0060090	molecular_function	molecular adaptor activity
E	0061702	cellular_component	canonical inflammasome complex
E	0070269	biological_process	pyroptotic inflammatory response
E	0070273	molecular_function	phosphatidylinositol-4-phosphate binding
E	0071222	biological_process	cellular response to lipopolysaccharide
E	0072559	cellular_component	NLRP3 inflammasome complex
E	0098586	biological_process	cellular response to virus
E	0140297	molecular_function	DNA-binding transcription factor binding
E	0140299	molecular_function	molecular sensor activity
E	0140608	molecular_function	cysteine-type endopeptidase activator activity
E	0140693	molecular_function	molecular condensate scaffold activity
E	1901223	biological_process	negative regulation of non-canonical NF-kappaB signal transduction
E	1901224	biological_process	positive regulation of non-canonical NF-kappaB signal transduction
E	1901981	molecular_function	phosphatidylinositol phosphate binding
E	2000553	biological_process	positive regulation of T-helper 2 cell cytokine production
F	0000139	cellular_component	Golgi membrane
F	0000166	molecular_function	nucleotide binding
F	0002221	biological_process	pattern recognition receptor signaling pathway
F	0002376	biological_process	immune system process
F	0002674	biological_process	negative regulation of acute inflammatory response
F	0002830	biological_process	positive regulation of type 2 immune response
F	0005515	molecular_function	protein binding
F	0005524	molecular_function	ATP binding
F	0005576	cellular_component	extracellular region
F	0005634	cellular_component	nucleus
F	0005737	cellular_component	cytoplasm
F	0005739	cellular_component	mitochondrion
F	0005783	cellular_component	endoplasmic reticulum
F	0005815	cellular_component	microtubule organizing center
F	0005829	cellular_component	cytosol
F	0006355	biological_process	regulation of DNA-templated transcription
F	0006915	biological_process	apoptotic process
F	0006952	biological_process	defense response
F	0006954	biological_process	inflammatory response
F	0007165	biological_process	signal transduction
F	0007231	biological_process	osmosensory signaling pathway
F	0009595	biological_process	detection of biotic stimulus
F	0009615	biological_process	response to virus
F	0016020	cellular_component	membrane
F	0016787	molecular_function	hydrolase activity
F	0016887	molecular_function	ATP hydrolysis activity
F	0030674	molecular_function	protein-macromolecule adaptor activity
F	0031021	cellular_component	interphase microtubule organizing center
F	0032691	biological_process	negative regulation of interleukin-1 beta production
F	0032731	biological_process	positive regulation of interleukin-1 beta production
F	0032753	biological_process	positive regulation of interleukin-4 production
F	0035591	molecular_function	signaling adaptor activity
F	0042802	molecular_function	identical protein binding
F	0042834	molecular_function	peptidoglycan binding
F	0043531	molecular_function	ADP binding
F	0043565	molecular_function	sequence-specific DNA binding
F	0044546	biological_process	NLRP3 inflammasome complex assembly
F	0045087	biological_process	innate immune response
F	0045630	biological_process	positive regulation of T-helper 2 cell differentiation
F	0045944	biological_process	positive regulation of transcription by RNA polymerase II
F	0050727	biological_process	regulation of inflammatory response
F	0050728	biological_process	negative regulation of inflammatory response
F	0050729	biological_process	positive regulation of inflammatory response
F	0051092	biological_process	positive regulation of NF-kappaB transcription factor activity
F	0051260	biological_process	protein homooligomerization
F	0051604	biological_process	protein maturation
F	0060090	molecular_function	molecular adaptor activity
F	0061702	cellular_component	canonical inflammasome complex
F	0070269	biological_process	pyroptotic inflammatory response
F	0070273	molecular_function	phosphatidylinositol-4-phosphate binding
F	0071222	biological_process	cellular response to lipopolysaccharide
F	0072559	cellular_component	NLRP3 inflammasome complex
F	0098586	biological_process	cellular response to virus
F	0140297	molecular_function	DNA-binding transcription factor binding
F	0140299	molecular_function	molecular sensor activity
F	0140608	molecular_function	cysteine-type endopeptidase activator activity
F	0140693	molecular_function	molecular condensate scaffold activity
F	1901223	biological_process	negative regulation of non-canonical NF-kappaB signal transduction
F	1901224	biological_process	positive regulation of non-canonical NF-kappaB signal transduction
F	1901981	molecular_function	phosphatidylinositol phosphate binding
F	2000553	biological_process	positive regulation of T-helper 2 cell cytokine production
G	0000139	cellular_component	Golgi membrane
G	0000166	molecular_function	nucleotide binding
G	0002221	biological_process	pattern recognition receptor signaling pathway
G	0002376	biological_process	immune system process
G	0002674	biological_process	negative regulation of acute inflammatory response
G	0002830	biological_process	positive regulation of type 2 immune response
G	0005515	molecular_function	protein binding
G	0005524	molecular_function	ATP binding
G	0005576	cellular_component	extracellular region
G	0005634	cellular_component	nucleus
G	0005737	cellular_component	cytoplasm
G	0005739	cellular_component	mitochondrion
G	0005783	cellular_component	endoplasmic reticulum
G	0005815	cellular_component	microtubule organizing center
G	0005829	cellular_component	cytosol
G	0006355	biological_process	regulation of DNA-templated transcription
G	0006915	biological_process	apoptotic process
G	0006952	biological_process	defense response
G	0006954	biological_process	inflammatory response
G	0007165	biological_process	signal transduction
G	0007231	biological_process	osmosensory signaling pathway
G	0009595	biological_process	detection of biotic stimulus
G	0009615	biological_process	response to virus
G	0016020	cellular_component	membrane
G	0016787	molecular_function	hydrolase activity
G	0016887	molecular_function	ATP hydrolysis activity
G	0030674	molecular_function	protein-macromolecule adaptor activity
G	0031021	cellular_component	interphase microtubule organizing center
G	0032691	biological_process	negative regulation of interleukin-1 beta production
G	0032731	biological_process	positive regulation of interleukin-1 beta production
G	0032753	biological_process	positive regulation of interleukin-4 production
G	0035591	molecular_function	signaling adaptor activity
G	0042802	molecular_function	identical protein binding
G	0042834	molecular_function	peptidoglycan binding
G	0043531	molecular_function	ADP binding
G	0043565	molecular_function	sequence-specific DNA binding
G	0044546	biological_process	NLRP3 inflammasome complex assembly
G	0045087	biological_process	innate immune response
G	0045630	biological_process	positive regulation of T-helper 2 cell differentiation
G	0045944	biological_process	positive regulation of transcription by RNA polymerase II
G	0050727	biological_process	regulation of inflammatory response
G	0050728	biological_process	negative regulation of inflammatory response
G	0050729	biological_process	positive regulation of inflammatory response
G	0051092	biological_process	positive regulation of NF-kappaB transcription factor activity
G	0051260	biological_process	protein homooligomerization
G	0051604	biological_process	protein maturation
G	0060090	molecular_function	molecular adaptor activity
G	0061702	cellular_component	canonical inflammasome complex
G	0070269	biological_process	pyroptotic inflammatory response
G	0070273	molecular_function	phosphatidylinositol-4-phosphate binding
G	0071222	biological_process	cellular response to lipopolysaccharide
G	0072559	cellular_component	NLRP3 inflammasome complex
G	0098586	biological_process	cellular response to virus
G	0140297	molecular_function	DNA-binding transcription factor binding
G	0140299	molecular_function	molecular sensor activity
G	0140608	molecular_function	cysteine-type endopeptidase activator activity
G	0140693	molecular_function	molecular condensate scaffold activity
G	1901223	biological_process	negative regulation of non-canonical NF-kappaB signal transduction
G	1901224	biological_process	positive regulation of non-canonical NF-kappaB signal transduction
G	1901981	molecular_function	phosphatidylinositol phosphate binding
G	2000553	biological_process	positive regulation of T-helper 2 cell cytokine production
H	0000139	cellular_component	Golgi membrane
H	0000166	molecular_function	nucleotide binding
H	0002221	biological_process	pattern recognition receptor signaling pathway
H	0002376	biological_process	immune system process
H	0002674	biological_process	negative regulation of acute inflammatory response
H	0002830	biological_process	positive regulation of type 2 immune response
H	0005515	molecular_function	protein binding
H	0005524	molecular_function	ATP binding
H	0005576	cellular_component	extracellular region
H	0005634	cellular_component	nucleus
H	0005737	cellular_component	cytoplasm
H	0005739	cellular_component	mitochondrion
H	0005783	cellular_component	endoplasmic reticulum
H	0005815	cellular_component	microtubule organizing center
H	0005829	cellular_component	cytosol
H	0006355	biological_process	regulation of DNA-templated transcription
H	0006915	biological_process	apoptotic process
H	0006952	biological_process	defense response
H	0006954	biological_process	inflammatory response
H	0007165	biological_process	signal transduction
H	0007231	biological_process	osmosensory signaling pathway
H	0009595	biological_process	detection of biotic stimulus
H	0009615	biological_process	response to virus
H	0016020	cellular_component	membrane
H	0016787	molecular_function	hydrolase activity
H	0016887	molecular_function	ATP hydrolysis activity
H	0030674	molecular_function	protein-macromolecule adaptor activity
H	0031021	cellular_component	interphase microtubule organizing center
H	0032691	biological_process	negative regulation of interleukin-1 beta production
H	0032731	biological_process	positive regulation of interleukin-1 beta production
H	0032753	biological_process	positive regulation of interleukin-4 production
H	0035591	molecular_function	signaling adaptor activity
H	0042802	molecular_function	identical protein binding
H	0042834	molecular_function	peptidoglycan binding
H	0043531	molecular_function	ADP binding
H	0043565	molecular_function	sequence-specific DNA binding
H	0044546	biological_process	NLRP3 inflammasome complex assembly
H	0045087	biological_process	innate immune response
H	0045630	biological_process	positive regulation of T-helper 2 cell differentiation
H	0045944	biological_process	positive regulation of transcription by RNA polymerase II
H	0050727	biological_process	regulation of inflammatory response
H	0050728	biological_process	negative regulation of inflammatory response
H	0050729	biological_process	positive regulation of inflammatory response
H	0051092	biological_process	positive regulation of NF-kappaB transcription factor activity
H	0051260	biological_process	protein homooligomerization
H	0051604	biological_process	protein maturation
H	0060090	molecular_function	molecular adaptor activity
H	0061702	cellular_component	canonical inflammasome complex
H	0070269	biological_process	pyroptotic inflammatory response
H	0070273	molecular_function	phosphatidylinositol-4-phosphate binding
H	0071222	biological_process	cellular response to lipopolysaccharide
H	0072559	cellular_component	NLRP3 inflammasome complex
H	0098586	biological_process	cellular response to virus
H	0140297	molecular_function	DNA-binding transcription factor binding
H	0140299	molecular_function	molecular sensor activity
H	0140608	molecular_function	cysteine-type endopeptidase activator activity
H	0140693	molecular_function	molecular condensate scaffold activity
H	1901223	biological_process	negative regulation of non-canonical NF-kappaB signal transduction
H	1901224	biological_process	positive regulation of non-canonical NF-kappaB signal transduction
H	1901981	molecular_function	phosphatidylinositol phosphate binding
H	2000553	biological_process	positive regulation of T-helper 2 cell cytokine production
I	0000139	cellular_component	Golgi membrane
I	0000166	molecular_function	nucleotide binding
I	0002221	biological_process	pattern recognition receptor signaling pathway
I	0002376	biological_process	immune system process
I	0002674	biological_process	negative regulation of acute inflammatory response
I	0002830	biological_process	positive regulation of type 2 immune response
I	0005515	molecular_function	protein binding
I	0005524	molecular_function	ATP binding
I	0005576	cellular_component	extracellular region
I	0005634	cellular_component	nucleus
I	0005737	cellular_component	cytoplasm
I	0005739	cellular_component	mitochondrion
I	0005783	cellular_component	endoplasmic reticulum
I	0005815	cellular_component	microtubule organizing center
I	0005829	cellular_component	cytosol
I	0006355	biological_process	regulation of DNA-templated transcription
I	0006915	biological_process	apoptotic process
I	0006952	biological_process	defense response
I	0006954	biological_process	inflammatory response
I	0007165	biological_process	signal transduction
I	0007231	biological_process	osmosensory signaling pathway
I	0009595	biological_process	detection of biotic stimulus
I	0009615	biological_process	response to virus
I	0016020	cellular_component	membrane
I	0016787	molecular_function	hydrolase activity
I	0016887	molecular_function	ATP hydrolysis activity
I	0030674	molecular_function	protein-macromolecule adaptor activity
I	0031021	cellular_component	interphase microtubule organizing center
I	0032691	biological_process	negative regulation of interleukin-1 beta production
I	0032731	biological_process	positive regulation of interleukin-1 beta production
I	0032753	biological_process	positive regulation of interleukin-4 production
I	0035591	molecular_function	signaling adaptor activity
I	0042802	molecular_function	identical protein binding
I	0042834	molecular_function	peptidoglycan binding
I	0043531	molecular_function	ADP binding
I	0043565	molecular_function	sequence-specific DNA binding
I	0044546	biological_process	NLRP3 inflammasome complex assembly
I	0045087	biological_process	innate immune response
I	0045630	biological_process	positive regulation of T-helper 2 cell differentiation
I	0045944	biological_process	positive regulation of transcription by RNA polymerase II
I	0050727	biological_process	regulation of inflammatory response
I	0050728	biological_process	negative regulation of inflammatory response
I	0050729	biological_process	positive regulation of inflammatory response
I	0051092	biological_process	positive regulation of NF-kappaB transcription factor activity
I	0051260	biological_process	protein homooligomerization
I	0051604	biological_process	protein maturation
I	0060090	molecular_function	molecular adaptor activity
I	0061702	cellular_component	canonical inflammasome complex
I	0070269	biological_process	pyroptotic inflammatory response
I	0070273	molecular_function	phosphatidylinositol-4-phosphate binding
I	0071222	biological_process	cellular response to lipopolysaccharide
I	0072559	cellular_component	NLRP3 inflammasome complex
I	0098586	biological_process	cellular response to virus
I	0140297	molecular_function	DNA-binding transcription factor binding
I	0140299	molecular_function	molecular sensor activity
I	0140608	molecular_function	cysteine-type endopeptidase activator activity
I	0140693	molecular_function	molecular condensate scaffold activity
I	1901223	biological_process	negative regulation of non-canonical NF-kappaB signal transduction
I	1901224	biological_process	positive regulation of non-canonical NF-kappaB signal transduction
I	1901981	molecular_function	phosphatidylinositol phosphate binding
I	2000553	biological_process	positive regulation of T-helper 2 cell cytokine production
J	0000139	cellular_component	Golgi membrane
J	0000166	molecular_function	nucleotide binding
J	0002221	biological_process	pattern recognition receptor signaling pathway
J	0002376	biological_process	immune system process
J	0002674	biological_process	negative regulation of acute inflammatory response
J	0002830	biological_process	positive regulation of type 2 immune response
J	0005515	molecular_function	protein binding
J	0005524	molecular_function	ATP binding
J	0005576	cellular_component	extracellular region
J	0005634	cellular_component	nucleus
J	0005737	cellular_component	cytoplasm
J	0005739	cellular_component	mitochondrion
J	0005783	cellular_component	endoplasmic reticulum
J	0005815	cellular_component	microtubule organizing center
J	0005829	cellular_component	cytosol
J	0006355	biological_process	regulation of DNA-templated transcription
J	0006915	biological_process	apoptotic process
J	0006952	biological_process	defense response
J	0006954	biological_process	inflammatory response
J	0007165	biological_process	signal transduction
J	0007231	biological_process	osmosensory signaling pathway
J	0009595	biological_process	detection of biotic stimulus
J	0009615	biological_process	response to virus
J	0016020	cellular_component	membrane
J	0016787	molecular_function	hydrolase activity
J	0016887	molecular_function	ATP hydrolysis activity
J	0030674	molecular_function	protein-macromolecule adaptor activity
J	0031021	cellular_component	interphase microtubule organizing center
J	0032691	biological_process	negative regulation of interleukin-1 beta production
J	0032731	biological_process	positive regulation of interleukin-1 beta production
J	0032753	biological_process	positive regulation of interleukin-4 production
J	0035591	molecular_function	signaling adaptor activity
J	0042802	molecular_function	identical protein binding
J	0042834	molecular_function	peptidoglycan binding
J	0043531	molecular_function	ADP binding
J	0043565	molecular_function	sequence-specific DNA binding
J	0044546	biological_process	NLRP3 inflammasome complex assembly
J	0045087	biological_process	innate immune response
J	0045630	biological_process	positive regulation of T-helper 2 cell differentiation
J	0045944	biological_process	positive regulation of transcription by RNA polymerase II
J	0050727	biological_process	regulation of inflammatory response
J	0050728	biological_process	negative regulation of inflammatory response
J	0050729	biological_process	positive regulation of inflammatory response
J	0051092	biological_process	positive regulation of NF-kappaB transcription factor activity
J	0051260	biological_process	protein homooligomerization
J	0051604	biological_process	protein maturation
J	0060090	molecular_function	molecular adaptor activity
J	0061702	cellular_component	canonical inflammasome complex
J	0070269	biological_process	pyroptotic inflammatory response
J	0070273	molecular_function	phosphatidylinositol-4-phosphate binding
J	0071222	biological_process	cellular response to lipopolysaccharide
J	0072559	cellular_component	NLRP3 inflammasome complex
J	0098586	biological_process	cellular response to virus
J	0140297	molecular_function	DNA-binding transcription factor binding
J	0140299	molecular_function	molecular sensor activity
J	0140608	molecular_function	cysteine-type endopeptidase activator activity
J	0140693	molecular_function	molecular condensate scaffold activity
J	1901223	biological_process	negative regulation of non-canonical NF-kappaB signal transduction
J	1901224	biological_process	positive regulation of non-canonical NF-kappaB signal transduction
J	1901981	molecular_function	phosphatidylinositol phosphate binding
J	2000553	biological_process	positive regulation of T-helper 2 cell cytokine production

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	3160
Details	Domain: {"description":"NACHT","evidences":[{"source":"PROSITE-ProRule","id":"PRU00136","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	200
Details	Repeat: {"description":"LRR 1"}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	210
Details	Repeat: {"description":"LRR 2"}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	200
Details	Repeat: {"description":"LRR 3"}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	210
Details	Repeat: {"description":"LRR 4"}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	200
Details	Repeat: {"description":"LRR 5"}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	210
Details	Repeat: {"description":"LRR 6"}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	200
Details	Repeat: {"description":"LRR 7"}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	210
Details	Repeat: {"description":"LRR 8"}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	210
Details	Repeat: {"description":"LRR 9"}

Chain

Residue

Details

---

site_id	SWS_FT_FI11
Number of Residues	6
Details	Region: {"description":"Required for binding to phosphatidylinositol 4-phosphate (PtdIns4P)","evidences":[{"source":"UniProtKB","id":"Q8R4B8","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI12
Number of Residues	40
Details	Motif: {"description":"KFERQ-like motif 1","evidences":[{"source":"PubMed","id":"36586411","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI13
Number of Residues	40
Details	Motif: {"description":"KFERQ-like motif 2","evidences":[{"source":"PubMed","id":"36586411","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI14
Number of Residues	40
Details	Motif: {"description":"KFERQ-like motif 3","evidences":[{"source":"PubMed","id":"36586411","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI15
Number of Residues	40
Details	Motif: {"description":"KFERQ-like motif 4","evidences":[{"source":"PubMed","id":"36586411","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI16
Number of Residues	10
Details	Binding site: {"evidences":[{"source":"PubMed","id":"35254907","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"36142182","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"36442502","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"7VTP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7ZGU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8EJ4","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI17
Number of Residues	80
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00136","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"17483456","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"34687713","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"35114687","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"35254907","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"36142182","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"36442502","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"7ALV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7PZC","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7VTP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7ZGU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8EJ4","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI18
Number of Residues	10
Details	Binding site: {"evidences":[{"source":"PubMed","id":"34687713","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"35114687","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"35254907","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"36142182","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"7ALV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7PZC","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7VTP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7ZGU","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI19
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"28465465","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI20
Number of Residues	2
Details	Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"PubMed","id":"28943315","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI21
Number of Residues	40
Details	Modified residue: {"description":"Phosphotyrosine; by BTK","evidences":[{"source":"PubMed","id":"34554188","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI22
Number of Residues	20
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"Q8R4B8","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI23
Number of Residues	40
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"28943315","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI24
Number of Residues	10
Details	Modified residue: {"description":"Phosphoserine; by MAPK8","evidences":[{"source":"PubMed","id":"35114687","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI25
Number of Residues	10
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"35114687","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI26
Number of Residues	10
Details	Modified residue: {"description":"Phosphoserine; by LATS1 and LATS2","evidences":[{"source":"PubMed","id":"39173637","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI27
Number of Residues	30
Details	Modified residue: {"description":"Phosphoserine; by CSNK1A1","evidences":[{"source":"PubMed","id":"34615873","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI28
Number of Residues	10
Details	Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"PubMed","id":"27043286","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI29
Number of Residues	12
Details	Lipidation: {"description":"S-palmitoyl cysteine","evidences":[{"source":"PubMed","id":"39173637","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI30
Number of Residues	30
Details	Lipidation: {"description":"S-palmitoyl cysteine","evidences":[{"source":"PubMed","id":"36586411","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI31
Number of Residues	20
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"PubMed","id":"37575012","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI32
Number of Residues	40
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"PubMed","id":"34615873","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI33
Number of Residues	10
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"PubMed","id":"26037928","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---