7PZC

Cryo-EM structure of the NLRP3 decamer bound to the inhibitor CRID3

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000139	cellular_component	Golgi membrane
A	0000166	molecular_function	nucleotide binding
A	0002221	biological_process	pattern recognition receptor signaling pathway
A	0002376	biological_process	immune system process
A	0002674	biological_process	negative regulation of acute inflammatory response
A	0002830	biological_process	positive regulation of type 2 immune response
A	0005515	molecular_function	protein binding
A	0005524	molecular_function	ATP binding
A	0005576	cellular_component	extracellular region
A	0005634	cellular_component	nucleus
A	0005737	cellular_component	cytoplasm
A	0005739	cellular_component	mitochondrion
A	0005783	cellular_component	endoplasmic reticulum
A	0005794	cellular_component	Golgi apparatus
A	0005815	cellular_component	microtubule organizing center
A	0005829	cellular_component	cytosol
A	0005856	cellular_component	cytoskeleton
A	0006355	biological_process	regulation of DNA-templated transcription
A	0006915	biological_process	apoptotic process
A	0006952	biological_process	defense response
A	0006954	biological_process	inflammatory response
A	0007165	biological_process	signal transduction
A	0007231	biological_process	osmosensory signaling pathway
A	0009306	biological_process	protein secretion
A	0009595	biological_process	detection of biotic stimulus
A	0009615	biological_process	response to virus
A	0016020	cellular_component	membrane
A	0016787	molecular_function	hydrolase activity
A	0016887	molecular_function	ATP hydrolysis activity
A	0030674	molecular_function	protein-macromolecule adaptor activity
A	0031021	cellular_component	interphase microtubule organizing center
A	0032691	biological_process	negative regulation of interleukin-1 beta production
A	0032731	biological_process	positive regulation of interleukin-1 beta production
A	0032741	biological_process	positive regulation of interleukin-18 production
A	0032753	biological_process	positive regulation of interleukin-4 production
A	0035591	molecular_function	signaling adaptor activity
A	0035655	biological_process	interleukin-18-mediated signaling pathway
A	0042802	molecular_function	identical protein binding
A	0042834	molecular_function	peptidoglycan binding
A	0043531	molecular_function	ADP binding
A	0043565	molecular_function	sequence-specific DNA binding
A	0044546	biological_process	NLRP3 inflammasome complex assembly
A	0045087	biological_process	innate immune response
A	0045630	biological_process	positive regulation of T-helper 2 cell differentiation
A	0045944	biological_process	positive regulation of transcription by RNA polymerase II
A	0050727	biological_process	regulation of inflammatory response
A	0050728	biological_process	negative regulation of inflammatory response
A	0050729	biological_process	positive regulation of inflammatory response
A	0051092	biological_process	positive regulation of NF-kappaB transcription factor activity
A	0051260	biological_process	protein homooligomerization
A	0051604	biological_process	protein maturation
A	0060090	molecular_function	molecular adaptor activity
A	0061702	cellular_component	canonical inflammasome complex
A	0070269	biological_process	pyroptotic inflammatory response
A	0070273	molecular_function	phosphatidylinositol-4-phosphate binding
A	0070498	biological_process	interleukin-1-mediated signaling pathway
A	0071222	biological_process	cellular response to lipopolysaccharide
A	0072559	cellular_component	NLRP3 inflammasome complex
A	0098586	biological_process	cellular response to virus
A	0140297	molecular_function	DNA-binding transcription factor binding
A	0140299	molecular_function	molecular sensor activity
A	0140608	molecular_function	cysteine-type endopeptidase activator activity
A	0140693	molecular_function	molecular condensate scaffold activity
A	1900227	biological_process	positive regulation of NLRP3 inflammasome complex assembly
A	1901223	biological_process	negative regulation of non-canonical NF-kappaB signal transduction
A	1901224	biological_process	positive regulation of non-canonical NF-kappaB signal transduction
A	1901981	molecular_function	phosphatidylinositol phosphate binding
A	2000553	biological_process	positive regulation of T-helper 2 cell cytokine production
B	0000139	cellular_component	Golgi membrane
B	0000166	molecular_function	nucleotide binding
B	0002221	biological_process	pattern recognition receptor signaling pathway
B	0002376	biological_process	immune system process
B	0002674	biological_process	negative regulation of acute inflammatory response
B	0002830	biological_process	positive regulation of type 2 immune response
B	0005515	molecular_function	protein binding
B	0005524	molecular_function	ATP binding
B	0005576	cellular_component	extracellular region
B	0005634	cellular_component	nucleus
B	0005737	cellular_component	cytoplasm
B	0005739	cellular_component	mitochondrion
B	0005783	cellular_component	endoplasmic reticulum
B	0005794	cellular_component	Golgi apparatus
B	0005815	cellular_component	microtubule organizing center
B	0005829	cellular_component	cytosol
B	0005856	cellular_component	cytoskeleton
B	0006355	biological_process	regulation of DNA-templated transcription
B	0006915	biological_process	apoptotic process
B	0006952	biological_process	defense response
B	0006954	biological_process	inflammatory response
B	0007165	biological_process	signal transduction
B	0007231	biological_process	osmosensory signaling pathway
B	0009306	biological_process	protein secretion
B	0009595	biological_process	detection of biotic stimulus
B	0009615	biological_process	response to virus
B	0016020	cellular_component	membrane
B	0016787	molecular_function	hydrolase activity
B	0016887	molecular_function	ATP hydrolysis activity
B	0030674	molecular_function	protein-macromolecule adaptor activity
B	0031021	cellular_component	interphase microtubule organizing center
B	0032691	biological_process	negative regulation of interleukin-1 beta production
B	0032731	biological_process	positive regulation of interleukin-1 beta production
B	0032741	biological_process	positive regulation of interleukin-18 production
B	0032753	biological_process	positive regulation of interleukin-4 production
B	0035591	molecular_function	signaling adaptor activity
B	0035655	biological_process	interleukin-18-mediated signaling pathway
B	0042802	molecular_function	identical protein binding
B	0042834	molecular_function	peptidoglycan binding
B	0043531	molecular_function	ADP binding
B	0043565	molecular_function	sequence-specific DNA binding
B	0044546	biological_process	NLRP3 inflammasome complex assembly
B	0045087	biological_process	innate immune response
B	0045630	biological_process	positive regulation of T-helper 2 cell differentiation
B	0045944	biological_process	positive regulation of transcription by RNA polymerase II
B	0050727	biological_process	regulation of inflammatory response
B	0050728	biological_process	negative regulation of inflammatory response
B	0050729	biological_process	positive regulation of inflammatory response
B	0051092	biological_process	positive regulation of NF-kappaB transcription factor activity
B	0051260	biological_process	protein homooligomerization
B	0051604	biological_process	protein maturation
B	0060090	molecular_function	molecular adaptor activity
B	0061702	cellular_component	canonical inflammasome complex
B	0070269	biological_process	pyroptotic inflammatory response
B	0070273	molecular_function	phosphatidylinositol-4-phosphate binding
B	0070498	biological_process	interleukin-1-mediated signaling pathway
B	0071222	biological_process	cellular response to lipopolysaccharide
B	0072559	cellular_component	NLRP3 inflammasome complex
B	0098586	biological_process	cellular response to virus
B	0140297	molecular_function	DNA-binding transcription factor binding
B	0140299	molecular_function	molecular sensor activity
B	0140608	molecular_function	cysteine-type endopeptidase activator activity
B	0140693	molecular_function	molecular condensate scaffold activity
B	1900227	biological_process	positive regulation of NLRP3 inflammasome complex assembly
B	1901223	biological_process	negative regulation of non-canonical NF-kappaB signal transduction
B	1901224	biological_process	positive regulation of non-canonical NF-kappaB signal transduction
B	1901981	molecular_function	phosphatidylinositol phosphate binding
B	2000553	biological_process	positive regulation of T-helper 2 cell cytokine production
C	0000139	cellular_component	Golgi membrane
C	0000166	molecular_function	nucleotide binding
C	0002221	biological_process	pattern recognition receptor signaling pathway
C	0002376	biological_process	immune system process
C	0002674	biological_process	negative regulation of acute inflammatory response
C	0002830	biological_process	positive regulation of type 2 immune response
C	0005515	molecular_function	protein binding
C	0005524	molecular_function	ATP binding
C	0005576	cellular_component	extracellular region
C	0005634	cellular_component	nucleus
C	0005737	cellular_component	cytoplasm
C	0005739	cellular_component	mitochondrion
C	0005783	cellular_component	endoplasmic reticulum
C	0005794	cellular_component	Golgi apparatus
C	0005815	cellular_component	microtubule organizing center
C	0005829	cellular_component	cytosol
C	0005856	cellular_component	cytoskeleton
C	0006355	biological_process	regulation of DNA-templated transcription
C	0006915	biological_process	apoptotic process
C	0006952	biological_process	defense response
C	0006954	biological_process	inflammatory response
C	0007165	biological_process	signal transduction
C	0007231	biological_process	osmosensory signaling pathway
C	0009306	biological_process	protein secretion
C	0009595	biological_process	detection of biotic stimulus
C	0009615	biological_process	response to virus
C	0016020	cellular_component	membrane
C	0016787	molecular_function	hydrolase activity
C	0016887	molecular_function	ATP hydrolysis activity
C	0030674	molecular_function	protein-macromolecule adaptor activity
C	0031021	cellular_component	interphase microtubule organizing center
C	0032691	biological_process	negative regulation of interleukin-1 beta production
C	0032731	biological_process	positive regulation of interleukin-1 beta production
C	0032741	biological_process	positive regulation of interleukin-18 production
C	0032753	biological_process	positive regulation of interleukin-4 production
C	0035591	molecular_function	signaling adaptor activity
C	0035655	biological_process	interleukin-18-mediated signaling pathway
C	0042802	molecular_function	identical protein binding
C	0042834	molecular_function	peptidoglycan binding
C	0043531	molecular_function	ADP binding
C	0043565	molecular_function	sequence-specific DNA binding
C	0044546	biological_process	NLRP3 inflammasome complex assembly
C	0045087	biological_process	innate immune response
C	0045630	biological_process	positive regulation of T-helper 2 cell differentiation
C	0045944	biological_process	positive regulation of transcription by RNA polymerase II
C	0050727	biological_process	regulation of inflammatory response
C	0050728	biological_process	negative regulation of inflammatory response
C	0050729	biological_process	positive regulation of inflammatory response
C	0051092	biological_process	positive regulation of NF-kappaB transcription factor activity
C	0051260	biological_process	protein homooligomerization
C	0051604	biological_process	protein maturation
C	0060090	molecular_function	molecular adaptor activity
C	0061702	cellular_component	canonical inflammasome complex
C	0070269	biological_process	pyroptotic inflammatory response
C	0070273	molecular_function	phosphatidylinositol-4-phosphate binding
C	0070498	biological_process	interleukin-1-mediated signaling pathway
C	0071222	biological_process	cellular response to lipopolysaccharide
C	0072559	cellular_component	NLRP3 inflammasome complex
C	0098586	biological_process	cellular response to virus
C	0140297	molecular_function	DNA-binding transcription factor binding
C	0140299	molecular_function	molecular sensor activity
C	0140608	molecular_function	cysteine-type endopeptidase activator activity
C	0140693	molecular_function	molecular condensate scaffold activity
C	1900227	biological_process	positive regulation of NLRP3 inflammasome complex assembly
C	1901223	biological_process	negative regulation of non-canonical NF-kappaB signal transduction
C	1901224	biological_process	positive regulation of non-canonical NF-kappaB signal transduction
C	1901981	molecular_function	phosphatidylinositol phosphate binding
C	2000553	biological_process	positive regulation of T-helper 2 cell cytokine production
D	0000139	cellular_component	Golgi membrane
D	0000166	molecular_function	nucleotide binding
D	0002221	biological_process	pattern recognition receptor signaling pathway
D	0002376	biological_process	immune system process
D	0002674	biological_process	negative regulation of acute inflammatory response
D	0002830	biological_process	positive regulation of type 2 immune response
D	0005515	molecular_function	protein binding
D	0005524	molecular_function	ATP binding
D	0005576	cellular_component	extracellular region
D	0005634	cellular_component	nucleus
D	0005737	cellular_component	cytoplasm
D	0005739	cellular_component	mitochondrion
D	0005783	cellular_component	endoplasmic reticulum
D	0005794	cellular_component	Golgi apparatus
D	0005815	cellular_component	microtubule organizing center
D	0005829	cellular_component	cytosol
D	0005856	cellular_component	cytoskeleton
D	0006355	biological_process	regulation of DNA-templated transcription
D	0006915	biological_process	apoptotic process
D	0006952	biological_process	defense response
D	0006954	biological_process	inflammatory response
D	0007165	biological_process	signal transduction
D	0007231	biological_process	osmosensory signaling pathway
D	0009306	biological_process	protein secretion
D	0009595	biological_process	detection of biotic stimulus
D	0009615	biological_process	response to virus
D	0016020	cellular_component	membrane
D	0016787	molecular_function	hydrolase activity
D	0016887	molecular_function	ATP hydrolysis activity
D	0030674	molecular_function	protein-macromolecule adaptor activity
D	0031021	cellular_component	interphase microtubule organizing center
D	0032691	biological_process	negative regulation of interleukin-1 beta production
D	0032731	biological_process	positive regulation of interleukin-1 beta production
D	0032741	biological_process	positive regulation of interleukin-18 production
D	0032753	biological_process	positive regulation of interleukin-4 production
D	0035591	molecular_function	signaling adaptor activity
D	0035655	biological_process	interleukin-18-mediated signaling pathway
D	0042802	molecular_function	identical protein binding
D	0042834	molecular_function	peptidoglycan binding
D	0043531	molecular_function	ADP binding
D	0043565	molecular_function	sequence-specific DNA binding
D	0044546	biological_process	NLRP3 inflammasome complex assembly
D	0045087	biological_process	innate immune response
D	0045630	biological_process	positive regulation of T-helper 2 cell differentiation
D	0045944	biological_process	positive regulation of transcription by RNA polymerase II
D	0050727	biological_process	regulation of inflammatory response
D	0050728	biological_process	negative regulation of inflammatory response
D	0050729	biological_process	positive regulation of inflammatory response
D	0051092	biological_process	positive regulation of NF-kappaB transcription factor activity
D	0051260	biological_process	protein homooligomerization
D	0051604	biological_process	protein maturation
D	0060090	molecular_function	molecular adaptor activity
D	0061702	cellular_component	canonical inflammasome complex
D	0070269	biological_process	pyroptotic inflammatory response
D	0070273	molecular_function	phosphatidylinositol-4-phosphate binding
D	0070498	biological_process	interleukin-1-mediated signaling pathway
D	0071222	biological_process	cellular response to lipopolysaccharide
D	0072559	cellular_component	NLRP3 inflammasome complex
D	0098586	biological_process	cellular response to virus
D	0140297	molecular_function	DNA-binding transcription factor binding
D	0140299	molecular_function	molecular sensor activity
D	0140608	molecular_function	cysteine-type endopeptidase activator activity
D	0140693	molecular_function	molecular condensate scaffold activity
D	1900227	biological_process	positive regulation of NLRP3 inflammasome complex assembly
D	1901223	biological_process	negative regulation of non-canonical NF-kappaB signal transduction
D	1901224	biological_process	positive regulation of non-canonical NF-kappaB signal transduction
D	1901981	molecular_function	phosphatidylinositol phosphate binding
D	2000553	biological_process	positive regulation of T-helper 2 cell cytokine production
E	0000139	cellular_component	Golgi membrane
E	0000166	molecular_function	nucleotide binding
E	0002221	biological_process	pattern recognition receptor signaling pathway
E	0002376	biological_process	immune system process
E	0002674	biological_process	negative regulation of acute inflammatory response
E	0002830	biological_process	positive regulation of type 2 immune response
E	0005515	molecular_function	protein binding
E	0005524	molecular_function	ATP binding
E	0005576	cellular_component	extracellular region
E	0005634	cellular_component	nucleus
E	0005737	cellular_component	cytoplasm
E	0005739	cellular_component	mitochondrion
E	0005783	cellular_component	endoplasmic reticulum
E	0005794	cellular_component	Golgi apparatus
E	0005815	cellular_component	microtubule organizing center
E	0005829	cellular_component	cytosol
E	0005856	cellular_component	cytoskeleton
E	0006355	biological_process	regulation of DNA-templated transcription
E	0006915	biological_process	apoptotic process
E	0006952	biological_process	defense response
E	0006954	biological_process	inflammatory response
E	0007165	biological_process	signal transduction
E	0007231	biological_process	osmosensory signaling pathway
E	0009306	biological_process	protein secretion
E	0009595	biological_process	detection of biotic stimulus
E	0009615	biological_process	response to virus
E	0016020	cellular_component	membrane
E	0016787	molecular_function	hydrolase activity
E	0016887	molecular_function	ATP hydrolysis activity
E	0030674	molecular_function	protein-macromolecule adaptor activity
E	0031021	cellular_component	interphase microtubule organizing center
E	0032691	biological_process	negative regulation of interleukin-1 beta production
E	0032731	biological_process	positive regulation of interleukin-1 beta production
E	0032741	biological_process	positive regulation of interleukin-18 production
E	0032753	biological_process	positive regulation of interleukin-4 production
E	0035591	molecular_function	signaling adaptor activity
E	0035655	biological_process	interleukin-18-mediated signaling pathway
E	0042802	molecular_function	identical protein binding
E	0042834	molecular_function	peptidoglycan binding
E	0043531	molecular_function	ADP binding
E	0043565	molecular_function	sequence-specific DNA binding
E	0044546	biological_process	NLRP3 inflammasome complex assembly
E	0045087	biological_process	innate immune response
E	0045630	biological_process	positive regulation of T-helper 2 cell differentiation
E	0045944	biological_process	positive regulation of transcription by RNA polymerase II
E	0050727	biological_process	regulation of inflammatory response
E	0050728	biological_process	negative regulation of inflammatory response
E	0050729	biological_process	positive regulation of inflammatory response
E	0051092	biological_process	positive regulation of NF-kappaB transcription factor activity
E	0051260	biological_process	protein homooligomerization
E	0051604	biological_process	protein maturation
E	0060090	molecular_function	molecular adaptor activity
E	0061702	cellular_component	canonical inflammasome complex
E	0070269	biological_process	pyroptotic inflammatory response
E	0070273	molecular_function	phosphatidylinositol-4-phosphate binding
E	0070498	biological_process	interleukin-1-mediated signaling pathway
E	0071222	biological_process	cellular response to lipopolysaccharide
E	0072559	cellular_component	NLRP3 inflammasome complex
E	0098586	biological_process	cellular response to virus
E	0140297	molecular_function	DNA-binding transcription factor binding
E	0140299	molecular_function	molecular sensor activity
E	0140608	molecular_function	cysteine-type endopeptidase activator activity
E	0140693	molecular_function	molecular condensate scaffold activity
E	1900227	biological_process	positive regulation of NLRP3 inflammasome complex assembly
E	1901223	biological_process	negative regulation of non-canonical NF-kappaB signal transduction
E	1901224	biological_process	positive regulation of non-canonical NF-kappaB signal transduction
E	1901981	molecular_function	phosphatidylinositol phosphate binding
E	2000553	biological_process	positive regulation of T-helper 2 cell cytokine production
F	0000139	cellular_component	Golgi membrane
F	0000166	molecular_function	nucleotide binding
F	0002221	biological_process	pattern recognition receptor signaling pathway
F	0002376	biological_process	immune system process
F	0002674	biological_process	negative regulation of acute inflammatory response
F	0002830	biological_process	positive regulation of type 2 immune response
F	0005515	molecular_function	protein binding
F	0005524	molecular_function	ATP binding
F	0005576	cellular_component	extracellular region
F	0005634	cellular_component	nucleus
F	0005737	cellular_component	cytoplasm
F	0005739	cellular_component	mitochondrion
F	0005783	cellular_component	endoplasmic reticulum
F	0005794	cellular_component	Golgi apparatus
F	0005815	cellular_component	microtubule organizing center
F	0005829	cellular_component	cytosol
F	0005856	cellular_component	cytoskeleton
F	0006355	biological_process	regulation of DNA-templated transcription
F	0006915	biological_process	apoptotic process
F	0006952	biological_process	defense response
F	0006954	biological_process	inflammatory response
F	0007165	biological_process	signal transduction
F	0007231	biological_process	osmosensory signaling pathway
F	0009306	biological_process	protein secretion
F	0009595	biological_process	detection of biotic stimulus
F	0009615	biological_process	response to virus
F	0016020	cellular_component	membrane
F	0016787	molecular_function	hydrolase activity
F	0016887	molecular_function	ATP hydrolysis activity
F	0030674	molecular_function	protein-macromolecule adaptor activity
F	0031021	cellular_component	interphase microtubule organizing center
F	0032691	biological_process	negative regulation of interleukin-1 beta production
F	0032731	biological_process	positive regulation of interleukin-1 beta production
F	0032741	biological_process	positive regulation of interleukin-18 production
F	0032753	biological_process	positive regulation of interleukin-4 production
F	0035591	molecular_function	signaling adaptor activity
F	0035655	biological_process	interleukin-18-mediated signaling pathway
F	0042802	molecular_function	identical protein binding
F	0042834	molecular_function	peptidoglycan binding
F	0043531	molecular_function	ADP binding
F	0043565	molecular_function	sequence-specific DNA binding
F	0044546	biological_process	NLRP3 inflammasome complex assembly
F	0045087	biological_process	innate immune response
F	0045630	biological_process	positive regulation of T-helper 2 cell differentiation
F	0045944	biological_process	positive regulation of transcription by RNA polymerase II
F	0050727	biological_process	regulation of inflammatory response
F	0050728	biological_process	negative regulation of inflammatory response
F	0050729	biological_process	positive regulation of inflammatory response
F	0051092	biological_process	positive regulation of NF-kappaB transcription factor activity
F	0051260	biological_process	protein homooligomerization
F	0051604	biological_process	protein maturation
F	0060090	molecular_function	molecular adaptor activity
F	0061702	cellular_component	canonical inflammasome complex
F	0070269	biological_process	pyroptotic inflammatory response
F	0070273	molecular_function	phosphatidylinositol-4-phosphate binding
F	0070498	biological_process	interleukin-1-mediated signaling pathway
F	0071222	biological_process	cellular response to lipopolysaccharide
F	0072559	cellular_component	NLRP3 inflammasome complex
F	0098586	biological_process	cellular response to virus
F	0140297	molecular_function	DNA-binding transcription factor binding
F	0140299	molecular_function	molecular sensor activity
F	0140608	molecular_function	cysteine-type endopeptidase activator activity
F	0140693	molecular_function	molecular condensate scaffold activity
F	1900227	biological_process	positive regulation of NLRP3 inflammasome complex assembly
F	1901223	biological_process	negative regulation of non-canonical NF-kappaB signal transduction
F	1901224	biological_process	positive regulation of non-canonical NF-kappaB signal transduction
F	1901981	molecular_function	phosphatidylinositol phosphate binding
F	2000553	biological_process	positive regulation of T-helper 2 cell cytokine production
G	0000139	cellular_component	Golgi membrane
G	0000166	molecular_function	nucleotide binding
G	0002221	biological_process	pattern recognition receptor signaling pathway
G	0002376	biological_process	immune system process
G	0002674	biological_process	negative regulation of acute inflammatory response
G	0002830	biological_process	positive regulation of type 2 immune response
G	0005515	molecular_function	protein binding
G	0005524	molecular_function	ATP binding
G	0005576	cellular_component	extracellular region
G	0005634	cellular_component	nucleus
G	0005737	cellular_component	cytoplasm
G	0005739	cellular_component	mitochondrion
G	0005783	cellular_component	endoplasmic reticulum
G	0005794	cellular_component	Golgi apparatus
G	0005815	cellular_component	microtubule organizing center
G	0005829	cellular_component	cytosol
G	0005856	cellular_component	cytoskeleton
G	0006355	biological_process	regulation of DNA-templated transcription
G	0006915	biological_process	apoptotic process
G	0006952	biological_process	defense response
G	0006954	biological_process	inflammatory response
G	0007165	biological_process	signal transduction
G	0007231	biological_process	osmosensory signaling pathway
G	0009306	biological_process	protein secretion
G	0009595	biological_process	detection of biotic stimulus
G	0009615	biological_process	response to virus
G	0016020	cellular_component	membrane
G	0016787	molecular_function	hydrolase activity
G	0016887	molecular_function	ATP hydrolysis activity
G	0030674	molecular_function	protein-macromolecule adaptor activity
G	0031021	cellular_component	interphase microtubule organizing center
G	0032691	biological_process	negative regulation of interleukin-1 beta production
G	0032731	biological_process	positive regulation of interleukin-1 beta production
G	0032741	biological_process	positive regulation of interleukin-18 production
G	0032753	biological_process	positive regulation of interleukin-4 production
G	0035591	molecular_function	signaling adaptor activity
G	0035655	biological_process	interleukin-18-mediated signaling pathway
G	0042802	molecular_function	identical protein binding
G	0042834	molecular_function	peptidoglycan binding
G	0043531	molecular_function	ADP binding
G	0043565	molecular_function	sequence-specific DNA binding
G	0044546	biological_process	NLRP3 inflammasome complex assembly
G	0045087	biological_process	innate immune response
G	0045630	biological_process	positive regulation of T-helper 2 cell differentiation
G	0045944	biological_process	positive regulation of transcription by RNA polymerase II
G	0050727	biological_process	regulation of inflammatory response
G	0050728	biological_process	negative regulation of inflammatory response
G	0050729	biological_process	positive regulation of inflammatory response
G	0051092	biological_process	positive regulation of NF-kappaB transcription factor activity
G	0051260	biological_process	protein homooligomerization
G	0051604	biological_process	protein maturation
G	0060090	molecular_function	molecular adaptor activity
G	0061702	cellular_component	canonical inflammasome complex
G	0070269	biological_process	pyroptotic inflammatory response
G	0070273	molecular_function	phosphatidylinositol-4-phosphate binding
G	0070498	biological_process	interleukin-1-mediated signaling pathway
G	0071222	biological_process	cellular response to lipopolysaccharide
G	0072559	cellular_component	NLRP3 inflammasome complex
G	0098586	biological_process	cellular response to virus
G	0140297	molecular_function	DNA-binding transcription factor binding
G	0140299	molecular_function	molecular sensor activity
G	0140608	molecular_function	cysteine-type endopeptidase activator activity
G	0140693	molecular_function	molecular condensate scaffold activity
G	1900227	biological_process	positive regulation of NLRP3 inflammasome complex assembly
G	1901223	biological_process	negative regulation of non-canonical NF-kappaB signal transduction
G	1901224	biological_process	positive regulation of non-canonical NF-kappaB signal transduction
G	1901981	molecular_function	phosphatidylinositol phosphate binding
G	2000553	biological_process	positive regulation of T-helper 2 cell cytokine production
H	0000139	cellular_component	Golgi membrane
H	0000166	molecular_function	nucleotide binding
H	0002221	biological_process	pattern recognition receptor signaling pathway
H	0002376	biological_process	immune system process
H	0002674	biological_process	negative regulation of acute inflammatory response
H	0002830	biological_process	positive regulation of type 2 immune response
H	0005515	molecular_function	protein binding
H	0005524	molecular_function	ATP binding
H	0005576	cellular_component	extracellular region
H	0005634	cellular_component	nucleus
H	0005737	cellular_component	cytoplasm
H	0005739	cellular_component	mitochondrion
H	0005783	cellular_component	endoplasmic reticulum
H	0005794	cellular_component	Golgi apparatus
H	0005815	cellular_component	microtubule organizing center
H	0005829	cellular_component	cytosol
H	0005856	cellular_component	cytoskeleton
H	0006355	biological_process	regulation of DNA-templated transcription
H	0006915	biological_process	apoptotic process
H	0006952	biological_process	defense response
H	0006954	biological_process	inflammatory response
H	0007165	biological_process	signal transduction
H	0007231	biological_process	osmosensory signaling pathway
H	0009306	biological_process	protein secretion
H	0009595	biological_process	detection of biotic stimulus
H	0009615	biological_process	response to virus
H	0016020	cellular_component	membrane
H	0016787	molecular_function	hydrolase activity
H	0016887	molecular_function	ATP hydrolysis activity
H	0030674	molecular_function	protein-macromolecule adaptor activity
H	0031021	cellular_component	interphase microtubule organizing center
H	0032691	biological_process	negative regulation of interleukin-1 beta production
H	0032731	biological_process	positive regulation of interleukin-1 beta production
H	0032741	biological_process	positive regulation of interleukin-18 production
H	0032753	biological_process	positive regulation of interleukin-4 production
H	0035591	molecular_function	signaling adaptor activity
H	0035655	biological_process	interleukin-18-mediated signaling pathway
H	0042802	molecular_function	identical protein binding
H	0042834	molecular_function	peptidoglycan binding
H	0043531	molecular_function	ADP binding
H	0043565	molecular_function	sequence-specific DNA binding
H	0044546	biological_process	NLRP3 inflammasome complex assembly
H	0045087	biological_process	innate immune response
H	0045630	biological_process	positive regulation of T-helper 2 cell differentiation
H	0045944	biological_process	positive regulation of transcription by RNA polymerase II
H	0050727	biological_process	regulation of inflammatory response
H	0050728	biological_process	negative regulation of inflammatory response
H	0050729	biological_process	positive regulation of inflammatory response
H	0051092	biological_process	positive regulation of NF-kappaB transcription factor activity
H	0051260	biological_process	protein homooligomerization
H	0051604	biological_process	protein maturation
H	0060090	molecular_function	molecular adaptor activity
H	0061702	cellular_component	canonical inflammasome complex
H	0070269	biological_process	pyroptotic inflammatory response
H	0070273	molecular_function	phosphatidylinositol-4-phosphate binding
H	0070498	biological_process	interleukin-1-mediated signaling pathway
H	0071222	biological_process	cellular response to lipopolysaccharide
H	0072559	cellular_component	NLRP3 inflammasome complex
H	0098586	biological_process	cellular response to virus
H	0140297	molecular_function	DNA-binding transcription factor binding
H	0140299	molecular_function	molecular sensor activity
H	0140608	molecular_function	cysteine-type endopeptidase activator activity
H	0140693	molecular_function	molecular condensate scaffold activity
H	1900227	biological_process	positive regulation of NLRP3 inflammasome complex assembly
H	1901223	biological_process	negative regulation of non-canonical NF-kappaB signal transduction
H	1901224	biological_process	positive regulation of non-canonical NF-kappaB signal transduction
H	1901981	molecular_function	phosphatidylinositol phosphate binding
H	2000553	biological_process	positive regulation of T-helper 2 cell cytokine production
I	0000139	cellular_component	Golgi membrane
I	0000166	molecular_function	nucleotide binding
I	0002221	biological_process	pattern recognition receptor signaling pathway
I	0002376	biological_process	immune system process
I	0002674	biological_process	negative regulation of acute inflammatory response
I	0002830	biological_process	positive regulation of type 2 immune response
I	0005515	molecular_function	protein binding
I	0005524	molecular_function	ATP binding
I	0005576	cellular_component	extracellular region
I	0005634	cellular_component	nucleus
I	0005737	cellular_component	cytoplasm
I	0005739	cellular_component	mitochondrion
I	0005783	cellular_component	endoplasmic reticulum
I	0005794	cellular_component	Golgi apparatus
I	0005815	cellular_component	microtubule organizing center
I	0005829	cellular_component	cytosol
I	0005856	cellular_component	cytoskeleton
I	0006355	biological_process	regulation of DNA-templated transcription
I	0006915	biological_process	apoptotic process
I	0006952	biological_process	defense response
I	0006954	biological_process	inflammatory response
I	0007165	biological_process	signal transduction
I	0007231	biological_process	osmosensory signaling pathway
I	0009306	biological_process	protein secretion
I	0009595	biological_process	detection of biotic stimulus
I	0009615	biological_process	response to virus
I	0016020	cellular_component	membrane
I	0016787	molecular_function	hydrolase activity
I	0016887	molecular_function	ATP hydrolysis activity
I	0030674	molecular_function	protein-macromolecule adaptor activity
I	0031021	cellular_component	interphase microtubule organizing center
I	0032691	biological_process	negative regulation of interleukin-1 beta production
I	0032731	biological_process	positive regulation of interleukin-1 beta production
I	0032741	biological_process	positive regulation of interleukin-18 production
I	0032753	biological_process	positive regulation of interleukin-4 production
I	0035591	molecular_function	signaling adaptor activity
I	0035655	biological_process	interleukin-18-mediated signaling pathway
I	0042802	molecular_function	identical protein binding
I	0042834	molecular_function	peptidoglycan binding
I	0043531	molecular_function	ADP binding
I	0043565	molecular_function	sequence-specific DNA binding
I	0044546	biological_process	NLRP3 inflammasome complex assembly
I	0045087	biological_process	innate immune response
I	0045630	biological_process	positive regulation of T-helper 2 cell differentiation
I	0045944	biological_process	positive regulation of transcription by RNA polymerase II
I	0050727	biological_process	regulation of inflammatory response
I	0050728	biological_process	negative regulation of inflammatory response
I	0050729	biological_process	positive regulation of inflammatory response
I	0051092	biological_process	positive regulation of NF-kappaB transcription factor activity
I	0051260	biological_process	protein homooligomerization
I	0051604	biological_process	protein maturation
I	0060090	molecular_function	molecular adaptor activity
I	0061702	cellular_component	canonical inflammasome complex
I	0070269	biological_process	pyroptotic inflammatory response
I	0070273	molecular_function	phosphatidylinositol-4-phosphate binding
I	0070498	biological_process	interleukin-1-mediated signaling pathway
I	0071222	biological_process	cellular response to lipopolysaccharide
I	0072559	cellular_component	NLRP3 inflammasome complex
I	0098586	biological_process	cellular response to virus
I	0140297	molecular_function	DNA-binding transcription factor binding
I	0140299	molecular_function	molecular sensor activity
I	0140608	molecular_function	cysteine-type endopeptidase activator activity
I	0140693	molecular_function	molecular condensate scaffold activity
I	1900227	biological_process	positive regulation of NLRP3 inflammasome complex assembly
I	1901223	biological_process	negative regulation of non-canonical NF-kappaB signal transduction
I	1901224	biological_process	positive regulation of non-canonical NF-kappaB signal transduction
I	1901981	molecular_function	phosphatidylinositol phosphate binding
I	2000553	biological_process	positive regulation of T-helper 2 cell cytokine production
J	0000139	cellular_component	Golgi membrane
J	0000166	molecular_function	nucleotide binding
J	0002221	biological_process	pattern recognition receptor signaling pathway
J	0002376	biological_process	immune system process
J	0002674	biological_process	negative regulation of acute inflammatory response
J	0002830	biological_process	positive regulation of type 2 immune response
J	0005515	molecular_function	protein binding
J	0005524	molecular_function	ATP binding
J	0005576	cellular_component	extracellular region
J	0005634	cellular_component	nucleus
J	0005737	cellular_component	cytoplasm
J	0005739	cellular_component	mitochondrion
J	0005783	cellular_component	endoplasmic reticulum
J	0005794	cellular_component	Golgi apparatus
J	0005815	cellular_component	microtubule organizing center
J	0005829	cellular_component	cytosol
J	0005856	cellular_component	cytoskeleton
J	0006355	biological_process	regulation of DNA-templated transcription
J	0006915	biological_process	apoptotic process
J	0006952	biological_process	defense response
J	0006954	biological_process	inflammatory response
J	0007165	biological_process	signal transduction
J	0007231	biological_process	osmosensory signaling pathway
J	0009306	biological_process	protein secretion
J	0009595	biological_process	detection of biotic stimulus
J	0009615	biological_process	response to virus
J	0016020	cellular_component	membrane
J	0016787	molecular_function	hydrolase activity
J	0016887	molecular_function	ATP hydrolysis activity
J	0030674	molecular_function	protein-macromolecule adaptor activity
J	0031021	cellular_component	interphase microtubule organizing center
J	0032691	biological_process	negative regulation of interleukin-1 beta production
J	0032731	biological_process	positive regulation of interleukin-1 beta production
J	0032741	biological_process	positive regulation of interleukin-18 production
J	0032753	biological_process	positive regulation of interleukin-4 production
J	0035591	molecular_function	signaling adaptor activity
J	0035655	biological_process	interleukin-18-mediated signaling pathway
J	0042802	molecular_function	identical protein binding
J	0042834	molecular_function	peptidoglycan binding
J	0043531	molecular_function	ADP binding
J	0043565	molecular_function	sequence-specific DNA binding
J	0044546	biological_process	NLRP3 inflammasome complex assembly
J	0045087	biological_process	innate immune response
J	0045630	biological_process	positive regulation of T-helper 2 cell differentiation
J	0045944	biological_process	positive regulation of transcription by RNA polymerase II
J	0050727	biological_process	regulation of inflammatory response
J	0050728	biological_process	negative regulation of inflammatory response
J	0050729	biological_process	positive regulation of inflammatory response
J	0051092	biological_process	positive regulation of NF-kappaB transcription factor activity
J	0051260	biological_process	protein homooligomerization
J	0051604	biological_process	protein maturation
J	0060090	molecular_function	molecular adaptor activity
J	0061702	cellular_component	canonical inflammasome complex
J	0070269	biological_process	pyroptotic inflammatory response
J	0070273	molecular_function	phosphatidylinositol-4-phosphate binding
J	0070498	biological_process	interleukin-1-mediated signaling pathway
J	0071222	biological_process	cellular response to lipopolysaccharide
J	0072559	cellular_component	NLRP3 inflammasome complex
J	0098586	biological_process	cellular response to virus
J	0140297	molecular_function	DNA-binding transcription factor binding
J	0140299	molecular_function	molecular sensor activity
J	0140608	molecular_function	cysteine-type endopeptidase activator activity
J	0140693	molecular_function	molecular condensate scaffold activity
J	1900227	biological_process	positive regulation of NLRP3 inflammasome complex assembly
J	1901223	biological_process	negative regulation of non-canonical NF-kappaB signal transduction
J	1901224	biological_process	positive regulation of non-canonical NF-kappaB signal transduction
J	1901981	molecular_function	phosphatidylinositol phosphate binding
J	2000553	biological_process	positive regulation of T-helper 2 cell cytokine production

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	10
Details	BINDING: BINDING => ECO:0000305|PubMed:35254907, ECO:0000305|PubMed:36142182, ECO:0000305|PubMed:36442502, ECO:0007744|PDB:7VTP, ECO:0007744|PDB:7ZGU, ECO:0007744|PDB:8EJ4

Chain	Residue	Details
A	THR169
J	THR169
B	THR169
C	THR169
D	THR169
E	THR169
F	THR169
G	THR169
H	THR169
I	THR169

---

site_id	SWS_FT_FI2
Number of Residues	10
Details	BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00136, ECO:0000269|PubMed:17483456, ECO:0000305|PubMed:34687713, ECO:0000305|PubMed:35114687, ECO:0000305|PubMed:35254907, ECO:0000305|PubMed:36142182, ECO:0000305|PubMed:36442502, ECO:0007744|PDB:7ALV, ECO:0007744|PDB:7PZC, ECO:0007744|PDB:7VTP, ECO:0007744|PDB:7ZGU, ECO:0007744|PDB:8EJ4

Chain	Residue	Details
A	GLY226
J	GLY226
B	GLY226
C	GLY226
D	GLY226
E	GLY226
F	GLY226
G	GLY226
H	GLY226
I	GLY226

---

site_id	SWS_FT_FI3
Number of Residues	10
Details	BINDING: BINDING => ECO:0000305|PubMed:34687713, ECO:0000305|PubMed:35114687, ECO:0000305|PubMed:35254907, ECO:0000305|PubMed:36142182, ECO:0007744|PDB:7ALV, ECO:0007744|PDB:7PZC, ECO:0007744|PDB:7VTP, ECO:0007744|PDB:7ZGU

Chain	Residue	Details
A	HIS522
J	HIS522
B	HIS522
C	HIS522
D	HIS522
E	HIS522
F	HIS522
G	HIS522
H	HIS522
I	HIS522

---

site_id	SWS_FT_FI4
Number of Residues	10
Details	MOD_RES: Phosphoserine => ECO:0000269|PubMed:28465465

Chain	Residue	Details
A	SER5
J	SER5
B	SER5
C	SER5
D	SER5
E	SER5
F	SER5
G	SER5
H	SER5
I	SER5

---

site_id	SWS_FT_FI5
Number of Residues	10
Details	MOD_RES: Phosphotyrosine => ECO:0000269|PubMed:28943315

Chain	Residue	Details
A	TYR13
J	TYR13
B	TYR13
C	TYR13
D	TYR13
E	TYR13
F	TYR13
G	TYR13
H	TYR13
I	TYR13

---

site_id	SWS_FT_FI6
Number of Residues	40
Details	MOD_RES: Phosphotyrosine; by BTK => ECO:0000269|PubMed:34554188

Chain	Residue	Details
A	TYR136
C	TYR140
C	TYR143
C	TYR168
D	TYR136
D	TYR140
D	TYR143
D	TYR168
E	TYR136
E	TYR140
E	TYR143
A	TYR140
E	TYR168
F	TYR136
F	TYR140
F	TYR143
F	TYR168
G	TYR136
G	TYR140
G	TYR143
G	TYR168
H	TYR136
A	TYR143
H	TYR140
H	TYR143
H	TYR168
I	TYR136
I	TYR140
I	TYR143
I	TYR168
J	TYR136
J	TYR140
J	TYR143
A	TYR168
J	TYR168
B	TYR136
B	TYR140
B	TYR143
B	TYR168
C	TYR136

---

site_id	SWS_FT_FI7
Number of Residues	20
Details	MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:Q8R4B8

Chain	Residue	Details
A	SER161
E	SER295
F	SER161
F	SER295
G	SER161
G	SER295
H	SER161
H	SER295
I	SER161
I	SER295
J	SER161
A	SER295
J	SER295
B	SER161
B	SER295
C	SER161
C	SER295
D	SER161
D	SER295
E	SER161

---

site_id	SWS_FT_FI8
Number of Residues	40
Details	MOD_RES: Phosphoserine => ECO:0000269|PubMed:28943315

Chain	Residue	Details
A	SER163
C	SER334
C	SER728
C	SER975
D	SER163
D	SER334
D	SER728
D	SER975
E	SER163
E	SER334
E	SER728
A	SER334
E	SER975
F	SER163
F	SER334
F	SER728
F	SER975
G	SER163
G	SER334
G	SER728
G	SER975
H	SER163
A	SER728
H	SER334
H	SER728
H	SER975
I	SER163
I	SER334
I	SER728
I	SER975
J	SER163
J	SER334
J	SER728
A	SER975
J	SER975
B	SER163
B	SER334
B	SER728
B	SER975
C	SER163

---

site_id	SWS_FT_FI9
Number of Residues	10
Details	MOD_RES: Phosphoserine; by MAPK8 => ECO:0000269|PubMed:35114687

Chain	Residue	Details
A	SER198
J	SER198
B	SER198
C	SER198
D	SER198
E	SER198
F	SER198
G	SER198
H	SER198
I	SER198

---

site_id	SWS_FT_FI10
Number of Residues	10
Details	MOD_RES: Phosphoserine => ECO:0000269|PubMed:35114687

Chain	Residue	Details
A	SER201
J	SER201
B	SER201
C	SER201
D	SER201
E	SER201
F	SER201
G	SER201
H	SER201
I	SER201

---

site_id	SWS_FT_FI11
Number of Residues	10
Details	MOD_RES: Phosphoserine; by LATS1 and LATS2 => ECO:0000269|PubMed:39173637

Chain	Residue	Details
A	SER265
J	SER265
B	SER265
C	SER265
D	SER265
E	SER265
F	SER265
G	SER265
H	SER265
I	SER265

---

site_id	SWS_FT_FI12
Number of Residues	30
Details	MOD_RES: Phosphoserine; by CSNK1A1 => ECO:0000269|PubMed:34615873

Chain	Residue	Details
A	SER735
D	SER735
D	SER806
D	SER1035
E	SER735
E	SER806
E	SER1035
F	SER735
F	SER806
F	SER1035
G	SER735
A	SER806
G	SER806
G	SER1035
H	SER735
H	SER806
H	SER1035
I	SER735
I	SER806
I	SER1035
J	SER735
J	SER806
A	SER1035
J	SER1035
B	SER735
B	SER806
B	SER1035
C	SER735
C	SER806
C	SER1035

---

site_id	SWS_FT_FI13
Number of Residues	10
Details	MOD_RES: Phosphotyrosine => ECO:0000269|PubMed:27043286

Chain	Residue	Details
A	TYR861
J	TYR861
B	TYR861
C	TYR861
D	TYR861
E	TYR861
F	TYR861
G	TYR861
H	TYR861
I	TYR861

---

site_id	SWS_FT_FI14
Number of Residues	20
Details	LIPID: S-palmitoyl cysteine => ECO:0000269|PubMed:39173637

Chain	Residue	Details
A	CYS130
E	CYS958
F	CYS130
F	CYS958
G	CYS130
G	CYS958
H	CYS130
H	CYS958
I	CYS130
I	CYS958
J	CYS130
A	CYS958
J	CYS958
B	CYS130
B	CYS958
C	CYS130
C	CYS958
D	CYS130
D	CYS958
E	CYS130

---

site_id	SWS_FT_FI15
Number of Residues	30
Details	LIPID: S-palmitoyl cysteine => ECO:0000269|PubMed:36586411

Chain	Residue	Details
A	CYS837
D	CYS837
D	CYS838
D	CYS844
E	CYS837
E	CYS838
E	CYS844
F	CYS837
F	CYS838
F	CYS844
G	CYS837
A	CYS838
G	CYS838
G	CYS844
H	CYS837
H	CYS838
H	CYS844
I	CYS837
I	CYS838
I	CYS844
J	CYS837
J	CYS838
A	CYS844
J	CYS844
B	CYS837
B	CYS838
B	CYS844
C	CYS837
C	CYS838
C	CYS844

---

site_id	SWS_FT_FI16
Number of Residues	10
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:26037928

Chain	Residue	Details
A	LYS689
J	LYS689
B	LYS689
C	LYS689
D	LYS689
E	LYS689
F	LYS689
G	LYS689
H	LYS689
I	LYS689

---

site_id	SWS_FT_FI17
Number of Residues	40
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:34615873

Chain	Residue	Details
C	LYS878
C	LYS927
C	LYS973
D	LYS878
D	LYS927
D	LYS973
E	LYS878
E	LYS927
A	LYS878
E	LYS973
F	LYS878
F	LYS927
F	LYS973
G	LYS878
G	LYS927
G	LYS973
A	LYS927
H	LYS878
H	LYS927
H	LYS973
I	LYS878
I	LYS927
I	LYS973
J	LYS878
J	LYS927
A	LYS973
J	LYS973
B	LYS878
B	LYS927
B	LYS973

---