7PWD

Structure of an inhibited GRK2-G-beta and G-gamma complex

Summary for 7PWD

• Entry DOI: 10.2210/pdb7pwd/pdb
• Descriptor: Beta-adrenergic receptor kinase 1, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... (8 entities in total)
• Functional Keywords: proteros, grk2, inhibition, heart failure, kinase, transferase
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 3
• Total formula weight: 127493.09

Authors

Faucher, N.,Tauchert, M.J.,Konz Makino, D.L.,Vuillard, L.M. (deposition date: 2021-10-06, release date: 2021-10-20, Last modification date: 2024-06-19)

• Primary citation: Balo, T.,Sapi, A.,Kiss, A.,Raimbaud, E.,Paysant, J.,Cattin, M.E.,Berger, S.,Kotschy, A.,Faucher, N.; Synthesis of thieno[2,3-c]pyridine derived GRK2 inhibitors; Monatsh Chem, 2022; DOI: 10.1007/s00706-021-02889-2

Experimental method

X-RAY DIFFRACTION (2.6 Å)