7PUE
Human serum and glucocorticoid-regulated kinase 1 in complex with pyrazolopyridine inhibitor 3a
Summary for 7PUE
Entry DOI | 10.2210/pdb7pue/pdb |
Descriptor | Serine/threonine-protein kinase Sgk1, GLYCEROL, 6-[4-[[2,3-bis(chloranyl)phenyl]sulfonylamino]phenyl]-~{N}-[(3~{R})-pyrrolidin-3-yl]-2~{H}-pyrazolo[3,4-b]pyridine-4-carboxamide, ... (4 entities in total) |
Functional Keywords | serine/threonine protein kinase, atp-competitive inhibitor, dfg-loop, hinge-binder, osteoarthritis, cartilage degradation, pyrazolo-pyridine, transferase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 43227.09 |
Authors | Dreyer, M.K.,Halland, N.,Nazare, M. (deposition date: 2021-09-29, release date: 2021-12-01, Last modification date: 2024-05-01) |
Primary citation | Halland, N.,Schmidt, F.,Weiss, T.,Li, Z.,Czech, J.,Saas, J.,Ding-Pfennigdorff, D.,Dreyer, M.K.,Strubing, C.,Nazare, M. Rational Design of Highly Potent, Selective, and Bioavailable SGK1 Protein Kinase Inhibitors for the Treatment of Osteoarthritis. J.Med.Chem., 65:1567-1584, 2022 Cited by PubMed: 34931844DOI: 10.1021/acs.jmedchem.1c01601 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.506 Å) |
Structure validation
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