7PQV
MEK1 IN COMPLEX WITH COMPOUND 7
Summary for 7PQV
Entry DOI | 10.2210/pdb7pqv/pdb |
Descriptor | Dual specificity mitogen-activated protein kinase kinase 1, 8-(2-chloranyl-4-methoxy-phenyl)-7-fluoranyl-1-piperidin-4-yl-imidazo[4,5-c]quinoline, CALCIUM ION, ... (5 entities in total) |
Functional Keywords | mek1 mitogen-activated protein kinase 1, kinase inhibitor, anti-cancer drug, signaling protein |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 39022.75 |
Authors | Moebitz, H. (deposition date: 2021-09-20, release date: 2022-03-16, Last modification date: 2024-06-19) |
Primary citation | Poddutoori, R.,Aardalen, K.,Aithal, K.,Barahagar, S.S.,Belliappa, C.,Bock, M.,Chelur, S.,Gerken, A.,Gopinath, S.,Gruenenfelder, B.,Kiffe, M.,Krishnaswami, M.,Langowski, J.,Madapa, S.,Narayanan, K.,Pandit, C.,Panigrahi, S.K.,Perrone, M.,Potakamuri, R.K.,Ramachandra, M.,Ramanathan, A.,Ramos, R.,Sager, E.,Samajdar, S.,Subramanya, H.S.,Thimmasandra, D.S.,Venetsanakos, E.,Mobitz, H. Discovery of MAP855, an Efficacious and Selective MEK1/2 Inhibitor with an ATP-Competitive Mode of Action. J.Med.Chem., 65:4350-4366, 2022 Cited by PubMed: 35195996DOI: 10.1021/acs.jmedchem.1c02192 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.13 Å) |
Structure validation
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