7PPI
Crystal STRUCTURE OF NAMPT IN COMPLEX WITH Compound 11
Summary for 7PPI
Entry DOI | 10.2210/pdb7ppi/pdb |
Descriptor | Nicotinamide phosphoribosyltransferase, N-[4-[(5R)-1-(4-azanylbutyl)-6-oxidanylidene-5-quinolin-5-yl-4,5-dihydropyridazin-3-yl]phenyl]-1,3-dihydropyrrolo[3,4-c]pyridine-2-carboxamide, PHOSPHATE ION, ... (6 entities in total) |
Functional Keywords | small molecule inhibitor, nmprtase, transferase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 4 |
Total formula weight | 225646.79 |
Authors | Hillig, R.C. (deposition date: 2021-09-13, release date: 2022-06-15, Last modification date: 2024-01-31) |
Primary citation | Bohnke, N.,Berger, M.,Griebenow, N.,Rottmann, A.,Erkelenz, M.,Hammer, S.,Berndt, S.,Gunther, J.,Wengner, A.M.,Stelte-Ludwig, B.,Mahlert, C.,Greven, S.,Dietz, L.,Jorissen, H.,Barak, N.,Bomer, U.,Hillig, R.C.,Eberspaecher, U.,Weiske, J.,Giese, A.,Mumberg, D.,Nising, C.F.,Weinmann, H.,Sommer, A. A Novel NAMPT Inhibitor-Based Antibody-Drug Conjugate Payload Class for Cancer Therapy. Bioconjug.Chem., 33:1210-1221, 2022 Cited by PubMed: 35658441DOI: 10.1021/acs.bioconjchem.2c00178 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.33 Å) |
Structure validation
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