7PNL
Complex between monomolecular human telomeric G-quadruplex and a sulfonamide derivative of the natural alkaloid Berberine
Summary for 7PNL
Entry DOI | 10.2210/pdb7pnl/pdb |
Descriptor | G-guadruplex DNA (23-mer), POTASSIUM ION, 4-[[1-[3-[(17-methoxy-5,7-dioxa-13-azoniapentacyclo[11.8.0.0^{2,10}.0^{4,8}.0^{15,20}]henicosa-1(21),2(10),3,8,13,15,17,19-octaen-16-yl)oxy]propyl]triazol-4-yl]methoxy]benzenesulfonamide, ... (4 entities in total) |
Functional Keywords | drug-dna complex, telomeric g-quadruplex, dna |
Biological source | Homo sapiens |
Total number of polymer chains | 1 |
Total formula weight | 8638.31 |
Authors | Bazzicalupi, C.,Gratteri, P.,Petreni, A.,Nocentini, A. (deposition date: 2021-09-07, release date: 2022-09-21, Last modification date: 2024-07-24) |
Primary citation | Nocentini, A.,Di Porzio, A.,Bonardi, A.,Bazzicalupi, C.,Petreni, A.,Biver, T.,Bua, S.,Marzano, S.,Amato, J.,Pagano, B.,Iaccarino, N.,De Tito, S.,Amente, S.,Supuran, C.T.,Randazzo, A.,Gratteri, P. Development of a multi-targeted chemotherapeutic approach based on G-quadruplex stabilisation and carbonic anhydrase inhibition. J Enzyme Inhib Med Chem, 39:2366236-2366236, 2024 Cited by PubMed: 38905127DOI: 10.1080/14756366.2024.2366236 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.83 Å) |
Structure validation
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