7PDW

Crystal structure of parent TCR (728) complexed to HLA-A*02:01 presenting MAGE-A10 9-mer peptide

This is a non-PDB format compatible entry.

Summary for 7PDW

• Entry DOI: 10.2210/pdb7pdw/pdb
• Related: 7PBC
• Descriptor: T-cell receptor alpha chain (TRAV/TRAC), T-cell receptor beta chain (TRBV/TRBC), Beta-2-microglobulin, ... (8 entities in total)
• Functional Keywords: t-cell receptor, human leukocyte antigen, mage-a10, immune system
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 10
• Total formula weight: 190280.19

Authors

Simister, P.C.,Border, E.C.,Vieira, J.F.,Pumphrey, N.J. (deposition date: 2021-08-09, release date: 2022-08-03, Last modification date: 2024-01-31)

• Primary citation: Simister, P.C.,Border, E.C.,Vieira, J.F.,Pumphrey, N.J.; Structural insights into engineering a T-cell receptor targeting MAGE-A10 with higher affinity and specificity for cancer immunotherapy.; J Immunother Cancer, 10:-, 2022; PubMed: 35851311; DOI: 10.1136/jitc-2022-004600

Experimental method

X-RAY DIFFRACTION (1.82 Å)