7PDW

Crystal structure of parent TCR (728) complexed to HLA-A*02:01 presenting MAGE-A10 9-mer peptide

This is a non-PDB format compatible entry.

Functional Information from GO Data

Chain	GOid	namespace	contents
DDD	0000139	cellular_component	Golgi membrane
DDD	0001913	biological_process	T cell mediated cytotoxicity
DDD	0001916	biological_process	positive regulation of T cell mediated cytotoxicity
DDD	0002237	biological_process	response to molecule of bacterial origin
DDD	0002474	biological_process	antigen processing and presentation of peptide antigen via MHC class I
DDD	0002481	biological_process	antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent
DDD	0002502	biological_process	peptide antigen assembly with MHC class I protein complex
DDD	0002503	biological_process	peptide antigen assembly with MHC class II protein complex
DDD	0002726	biological_process	positive regulation of T cell cytokine production
DDD	0005198	molecular_function	structural molecule activity
DDD	0005515	molecular_function	protein binding
DDD	0005576	cellular_component	extracellular region
DDD	0005615	cellular_component	extracellular space
DDD	0005765	cellular_component	lysosomal membrane
DDD	0005783	cellular_component	endoplasmic reticulum
DDD	0005788	cellular_component	endoplasmic reticulum lumen
DDD	0005794	cellular_component	Golgi apparatus
DDD	0005829	cellular_component	cytosol
DDD	0005886	cellular_component	plasma membrane
DDD	0005925	cellular_component	focal adhesion
DDD	0006826	biological_process	iron ion transport
DDD	0006879	biological_process	intracellular iron ion homeostasis
DDD	0006955	biological_process	immune response
DDD	0007608	biological_process	sensory perception of smell
DDD	0007611	biological_process	learning or memory
DDD	0009897	cellular_component	external side of plasma membrane
DDD	0009986	cellular_component	cell surface
DDD	0010977	biological_process	negative regulation of neuron projection development
DDD	0012507	cellular_component	ER to Golgi transport vesicle membrane
DDD	0016020	cellular_component	membrane
DDD	0019885	biological_process	antigen processing and presentation of endogenous peptide antigen via MHC class I
DDD	0019886	biological_process	antigen processing and presentation of exogenous peptide antigen via MHC class II
DDD	0023026	molecular_function	MHC class II protein complex binding
DDD	0030670	cellular_component	phagocytic vesicle membrane
DDD	0031901	cellular_component	early endosome membrane
DDD	0031902	cellular_component	late endosome membrane
DDD	0031905	cellular_component	early endosome lumen
DDD	0032092	biological_process	positive regulation of protein binding
DDD	0033077	biological_process	T cell differentiation in thymus
DDD	0034756	biological_process	regulation of iron ion transport
DDD	0035580	cellular_component	specific granule lumen
DDD	0042026	biological_process	protein refolding
DDD	0042605	molecular_function	peptide antigen binding
DDD	0042612	cellular_component	MHC class I protein complex
DDD	0042613	cellular_component	MHC class II protein complex
DDD	0042802	molecular_function	identical protein binding
DDD	0042803	molecular_function	protein homodimerization activity
DDD	0042824	cellular_component	MHC class I peptide loading complex
DDD	0045646	biological_process	regulation of erythrocyte differentiation
DDD	0048260	biological_process	positive regulation of receptor-mediated endocytosis
DDD	0050680	biological_process	negative regulation of epithelial cell proliferation
DDD	0050768	biological_process	negative regulation of neurogenesis
DDD	0050778	biological_process	positive regulation of immune response
DDD	0050870	biological_process	positive regulation of T cell activation
DDD	0051289	biological_process	protein homotetramerization
DDD	0055038	cellular_component	recycling endosome membrane
DDD	0060586	biological_process	multicellular organismal-level iron ion homeostasis
DDD	0070062	cellular_component	extracellular exosome
DDD	0071281	biological_process	cellular response to iron ion
DDD	0071283	biological_process	cellular response to iron(III) ion
DDD	0071316	biological_process	cellular response to nicotine
DDD	1900121	biological_process	negative regulation of receptor binding
DDD	1900122	biological_process	positive regulation of receptor binding
DDD	1904434	biological_process	positive regulation of ferrous iron binding
DDD	1904437	biological_process	positive regulation of transferrin receptor binding
DDD	1904724	cellular_component	tertiary granule lumen
DDD	1990000	biological_process	amyloid fibril formation
DDD	1990712	cellular_component	HFE-transferrin receptor complex
DDD	2000774	biological_process	positive regulation of cellular senescence
DDD	2000978	biological_process	negative regulation of forebrain neuron differentiation
III	0000139	cellular_component	Golgi membrane
III	0001913	biological_process	T cell mediated cytotoxicity
III	0001916	biological_process	positive regulation of T cell mediated cytotoxicity
III	0002237	biological_process	response to molecule of bacterial origin
III	0002474	biological_process	antigen processing and presentation of peptide antigen via MHC class I
III	0002481	biological_process	antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent
III	0002502	biological_process	peptide antigen assembly with MHC class I protein complex
III	0002503	biological_process	peptide antigen assembly with MHC class II protein complex
III	0002726	biological_process	positive regulation of T cell cytokine production
III	0005198	molecular_function	structural molecule activity
III	0005515	molecular_function	protein binding
III	0005576	cellular_component	extracellular region
III	0005615	cellular_component	extracellular space
III	0005765	cellular_component	lysosomal membrane
III	0005783	cellular_component	endoplasmic reticulum
III	0005788	cellular_component	endoplasmic reticulum lumen
III	0005794	cellular_component	Golgi apparatus
III	0005829	cellular_component	cytosol
III	0005886	cellular_component	plasma membrane
III	0005925	cellular_component	focal adhesion
III	0006826	biological_process	iron ion transport
III	0006879	biological_process	intracellular iron ion homeostasis
III	0006955	biological_process	immune response
III	0007608	biological_process	sensory perception of smell
III	0007611	biological_process	learning or memory
III	0009897	cellular_component	external side of plasma membrane
III	0009986	cellular_component	cell surface
III	0010977	biological_process	negative regulation of neuron projection development
III	0012507	cellular_component	ER to Golgi transport vesicle membrane
III	0016020	cellular_component	membrane
III	0019885	biological_process	antigen processing and presentation of endogenous peptide antigen via MHC class I
III	0019886	biological_process	antigen processing and presentation of exogenous peptide antigen via MHC class II
III	0023026	molecular_function	MHC class II protein complex binding
III	0030670	cellular_component	phagocytic vesicle membrane
III	0031901	cellular_component	early endosome membrane
III	0031902	cellular_component	late endosome membrane
III	0031905	cellular_component	early endosome lumen
III	0032092	biological_process	positive regulation of protein binding
III	0033077	biological_process	T cell differentiation in thymus
III	0034756	biological_process	regulation of iron ion transport
III	0035580	cellular_component	specific granule lumen
III	0042026	biological_process	protein refolding
III	0042605	molecular_function	peptide antigen binding
III	0042612	cellular_component	MHC class I protein complex
III	0042613	cellular_component	MHC class II protein complex
III	0042802	molecular_function	identical protein binding
III	0042803	molecular_function	protein homodimerization activity
III	0042824	cellular_component	MHC class I peptide loading complex
III	0045646	biological_process	regulation of erythrocyte differentiation
III	0048260	biological_process	positive regulation of receptor-mediated endocytosis
III	0050680	biological_process	negative regulation of epithelial cell proliferation
III	0050768	biological_process	negative regulation of neurogenesis
III	0050778	biological_process	positive regulation of immune response
III	0050870	biological_process	positive regulation of T cell activation
III	0051289	biological_process	protein homotetramerization
III	0055038	cellular_component	recycling endosome membrane
III	0060586	biological_process	multicellular organismal-level iron ion homeostasis
III	0070062	cellular_component	extracellular exosome
III	0071281	biological_process	cellular response to iron ion
III	0071283	biological_process	cellular response to iron(III) ion
III	0071316	biological_process	cellular response to nicotine
III	1900121	biological_process	negative regulation of receptor binding
III	1900122	biological_process	positive regulation of receptor binding
III	1904434	biological_process	positive regulation of ferrous iron binding
III	1904437	biological_process	positive regulation of transferrin receptor binding
III	1904724	cellular_component	tertiary granule lumen
III	1990000	biological_process	amyloid fibril formation
III	1990712	cellular_component	HFE-transferrin receptor complex
III	2000774	biological_process	positive regulation of cellular senescence
III	2000978	biological_process	negative regulation of forebrain neuron differentiation

Functional Information from PROSITE/UniProt

site_id	PS00290
Number of Residues	7
Details	IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YTCHVQH

Chain	Residue	Details
CCC	TYR258-HIS264
DDD	TYR79-HIS85

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	MOD_RES: Pyrrolidone carboxylic acid; in form pI 5.3 => ECO:0000269|PubMed:7554280

Chain	Residue	Details
DDD	GLN3
III	GLN3

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site_id	SWS_FT_FI2
Number of Residues	2
Details	CARBOHYD: N-linked (Glc) (glycation) isoleucine; in hemodialysis-associated amyloidosis => ECO:0000269|PubMed:7918443

Chain	Residue	Details
DDD	ILE2
III	ILE2

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site_id	SWS_FT_FI3
Number of Residues	12
Details	CARBOHYD: N-linked (Glc) (glycation) lysine; in vitro => ECO:0000269|PubMed:7918443

Chain	Residue	Details
DDD	LYS20
III	LYS59
III	LYS92
III	LYS95
DDD	LYS42
DDD	LYS49
DDD	LYS59
DDD	LYS92
DDD	LYS95
III	LYS20
III	LYS42
III	LYS49

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