Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

7PDW

Crystal structure of parent TCR (728) complexed to HLA-A*02:01 presenting MAGE-A10 9-mer peptide

This is a non-PDB format compatible entry.

Functional Information from GO Data

Chain	GOid	namespace	contents
DDD	0000139	cellular_component	Golgi membrane
DDD	0002376	biological_process	immune system process
DDD	0002474	biological_process	antigen processing and presentation of peptide antigen via MHC class I
DDD	0002477	biological_process	antigen processing and presentation of exogenous peptide antigen via MHC class Ib
DDD	0002502	biological_process	peptide antigen assembly with MHC class I protein complex
DDD	0002503	biological_process	peptide antigen assembly with MHC class II protein complex
DDD	0002715	biological_process	regulation of natural killer cell mediated immunity
DDD	0002726	biological_process	positive regulation of T cell cytokine production
DDD	0005198	molecular_function	structural molecule activity
DDD	0005515	molecular_function	protein binding
DDD	0005576	cellular_component	extracellular region
DDD	0005615	cellular_component	extracellular space
DDD	0005765	cellular_component	lysosomal membrane
DDD	0005783	cellular_component	endoplasmic reticulum
DDD	0005788	cellular_component	endoplasmic reticulum lumen
DDD	0005794	cellular_component	Golgi apparatus
DDD	0005886	cellular_component	plasma membrane
DDD	0005925	cellular_component	focal adhesion
DDD	0006879	biological_process	intracellular iron ion homeostasis
DDD	0006955	biological_process	immune response
DDD	0007608	biological_process	sensory perception of smell
DDD	0007611	biological_process	learning or memory
DDD	0009897	cellular_component	external side of plasma membrane
DDD	0009986	cellular_component	cell surface
DDD	0010038	biological_process	response to metal ion
DDD	0012507	cellular_component	ER to Golgi transport vesicle membrane
DDD	0016020	cellular_component	membrane
DDD	0019885	biological_process	antigen processing and presentation of endogenous peptide antigen via MHC class I
DDD	0019886	biological_process	antigen processing and presentation of exogenous peptide antigen via MHC class II
DDD	0023026	molecular_function	MHC class II protein complex binding
DDD	0030670	cellular_component	phagocytic vesicle membrane
DDD	0031901	cellular_component	early endosome membrane
DDD	0031902	cellular_component	late endosome membrane
DDD	0031905	cellular_component	early endosome lumen
DDD	0032398	cellular_component	MHC class Ib protein complex
DDD	0033572	biological_process	transferrin transport
DDD	0034756	biological_process	regulation of iron ion transport
DDD	0034757	biological_process	negative regulation of iron ion transport
DDD	0035580	cellular_component	specific granule lumen
DDD	0042605	molecular_function	peptide antigen binding
DDD	0042612	cellular_component	MHC class I protein complex
DDD	0042613	cellular_component	MHC class II protein complex
DDD	0042802	molecular_function	identical protein binding
DDD	0042803	molecular_function	protein homodimerization activity
DDD	0042824	cellular_component	MHC class I peptide loading complex
DDD	0048260	biological_process	positive regulation of receptor-mediated endocytosis
DDD	0048261	biological_process	negative regulation of receptor-mediated endocytosis
DDD	0050680	biological_process	negative regulation of epithelial cell proliferation
DDD	0050768	biological_process	negative regulation of neurogenesis
DDD	0050778	biological_process	positive regulation of immune response
DDD	0050870	biological_process	positive regulation of T cell activation
DDD	0051289	biological_process	protein homotetramerization
DDD	0055038	cellular_component	recycling endosome membrane
DDD	0070062	cellular_component	extracellular exosome
DDD	0071281	biological_process	cellular response to iron ion
DDD	0071316	biological_process	cellular response to nicotine
DDD	1904724	cellular_component	tertiary granule lumen
DDD	1990000	biological_process	amyloid fibril formation
DDD	1990712	cellular_component	HFE-transferrin receptor complex
DDD	2000774	biological_process	positive regulation of cellular senescence
DDD	2000978	biological_process	negative regulation of forebrain neuron differentiation
III	0000139	cellular_component	Golgi membrane
III	0002376	biological_process	immune system process
III	0002474	biological_process	antigen processing and presentation of peptide antigen via MHC class I
III	0002477	biological_process	antigen processing and presentation of exogenous peptide antigen via MHC class Ib
III	0002502	biological_process	peptide antigen assembly with MHC class I protein complex
III	0002503	biological_process	peptide antigen assembly with MHC class II protein complex
III	0002715	biological_process	regulation of natural killer cell mediated immunity
III	0002726	biological_process	positive regulation of T cell cytokine production
III	0005198	molecular_function	structural molecule activity
III	0005515	molecular_function	protein binding
III	0005576	cellular_component	extracellular region
III	0005615	cellular_component	extracellular space
III	0005765	cellular_component	lysosomal membrane
III	0005783	cellular_component	endoplasmic reticulum
III	0005788	cellular_component	endoplasmic reticulum lumen
III	0005794	cellular_component	Golgi apparatus
III	0005886	cellular_component	plasma membrane
III	0005925	cellular_component	focal adhesion
III	0006879	biological_process	intracellular iron ion homeostasis
III	0006955	biological_process	immune response
III	0007608	biological_process	sensory perception of smell
III	0007611	biological_process	learning or memory
III	0009897	cellular_component	external side of plasma membrane
III	0009986	cellular_component	cell surface
III	0010038	biological_process	response to metal ion
III	0012507	cellular_component	ER to Golgi transport vesicle membrane
III	0016020	cellular_component	membrane
III	0019885	biological_process	antigen processing and presentation of endogenous peptide antigen via MHC class I
III	0019886	biological_process	antigen processing and presentation of exogenous peptide antigen via MHC class II
III	0023026	molecular_function	MHC class II protein complex binding
III	0030670	cellular_component	phagocytic vesicle membrane
III	0031901	cellular_component	early endosome membrane
III	0031902	cellular_component	late endosome membrane
III	0031905	cellular_component	early endosome lumen
III	0032398	cellular_component	MHC class Ib protein complex
III	0033572	biological_process	transferrin transport
III	0034756	biological_process	regulation of iron ion transport
III	0034757	biological_process	negative regulation of iron ion transport
III	0035580	cellular_component	specific granule lumen
III	0042605	molecular_function	peptide antigen binding
III	0042612	cellular_component	MHC class I protein complex
III	0042613	cellular_component	MHC class II protein complex
III	0042802	molecular_function	identical protein binding
III	0042803	molecular_function	protein homodimerization activity
III	0042824	cellular_component	MHC class I peptide loading complex
III	0048260	biological_process	positive regulation of receptor-mediated endocytosis
III	0048261	biological_process	negative regulation of receptor-mediated endocytosis
III	0050680	biological_process	negative regulation of epithelial cell proliferation
III	0050768	biological_process	negative regulation of neurogenesis
III	0050778	biological_process	positive regulation of immune response
III	0050870	biological_process	positive regulation of T cell activation
III	0051289	biological_process	protein homotetramerization
III	0055038	cellular_component	recycling endosome membrane
III	0070062	cellular_component	extracellular exosome
III	0071281	biological_process	cellular response to iron ion
III	0071316	biological_process	cellular response to nicotine
III	1904724	cellular_component	tertiary granule lumen
III	1990000	biological_process	amyloid fibril formation
III	1990712	cellular_component	HFE-transferrin receptor complex
III	2000774	biological_process	positive regulation of cellular senescence
III	2000978	biological_process	negative regulation of forebrain neuron differentiation

Functional Information from PROSITE/UniProt

site_id	PS00290
Number of Residues	7
Details	IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YACRVNH

Chain	Residue	Details
DDD	TYR79-HIS85
CCC	TYR258-HIS264

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	176
Details	Domain: {"description":"Ig-like C1-type"}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	2
Details	Modified residue: {"description":"Pyrrolidone carboxylic acid; in form pI 5.3","evidences":[{"source":"PubMed","id":"7554280","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	2
Details	Glycosylation: {"description":"N-linked (Glc) (glycation) isoleucine; in hemodialysis-associated amyloidosis","evidences":[{"source":"PubMed","id":"7918443","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	12
Details	Glycosylation: {"description":"N-linked (Glc) (glycation) lysine; in vitro","evidences":[{"source":"PubMed","id":"7918443","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)