7OFD
Keap1 kelch domain bound to a small molecule fragment
Summary for 7OFD
Entry DOI | 10.2210/pdb7ofd/pdb |
Descriptor | Kelch-like ECH-associated protein 1, SULFATE ION, DIMETHYL SULFOXIDE, ... (5 entities in total) |
Functional Keywords | keap1, nrf2, oxidative stress, small molecule complex, maybridge, peptide binding protein |
Biological source | Mus musculus (Mouse) |
Total number of polymer chains | 1 |
Total formula weight | 34591.06 |
Authors | Narayanan, D.,Bach, A.,Gajhede, M. (deposition date: 2021-05-04, release date: 2022-11-02, Last modification date: 2024-01-31) |
Primary citation | Narayanan, D.,Tran, K.T.,Pallesen, J.S.,Solbak, S.M.O.,Qin, Y.,Mukminova, E.,Luchini, M.,Vasilyeva, K.O.,Gonzalez Chichon, D.,Goutsiou, G.,Poulsen, C.,Haapanen, N.,Popowicz, G.M.,Sattler, M.,Olagnier, D.,Gajhede, M.,Bach, A. Development of Noncovalent Small-Molecule Keap1-Nrf2 Inhibitors by Fragment-Based Drug Discovery. J.Med.Chem., 65:14481-14526, 2022 Cited by PubMed: 36263945DOI: 10.1021/acs.jmedchem.2c00830 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.25 Å) |
Structure validation
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