7O27
Crystal structure of the human METTL3-METTL14 complex bound to Compound 17 (ADO_AE_005)
Summary for 7O27
Entry DOI | 10.2210/pdb7o27/pdb |
Descriptor | N6-adenosine-methyltransferase catalytic subunit, N6-adenosine-methyltransferase non-catalytic subunit, 4-[4-[(4,4-dimethylpiperidin-1-yl)methyl]phenyl]-9-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1,4,9-triazaspiro[5.5]undecan-2-one, ... (5 entities in total) |
Functional Keywords | mettl3, inhibitor, complex, transferase |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 2 |
Total formula weight | 62312.01 |
Authors | Bedi, R.K.,Dolbois, A.,Caflisch, A. (deposition date: 2021-03-30, release date: 2021-09-15, Last modification date: 2024-01-31) |
Primary citation | Bedi, R.K.,Dolbois, A.,Caflisch, A. Crystal structure of the human METTL3-METTL14 complex bound to Compound 17 (ADO_AE_005) To Be Published, |
Experimental method | X-RAY DIFFRACTION (2.4 Å) |
Structure validation
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