7NRO

Crystal structure of AlkB in complex with manganese and N-(4-((6-((carboxymethyl)carbamoyl)-5-hydroxypyridin-2-yl)amino)phenyl)-N-oxohydroxylammonium

Summary for 7NRO

• Entry DOI: 10.2210/pdb7nro/pdb
• Related: 3T3Y
• Descriptor: Alpha-ketoglutarate-dependent dioxygenase AlkB, 2-[[6-[(4-nitrophenyl)amino]-3-oxidanyl-pyridin-2-yl]carbonylamino]ethanoic acid, MANGANESE (II) ION, ... (4 entities in total)
• Functional Keywords: alpha ketoglutarate and iron dependent oxygenase, dna demethylase, inhibitor complex, oxidoreductase
• Biological source: Escherichia coli K-12
• Total number of polymer chains: 1
• Total formula weight: 24491.72

Authors

Shishodia, S.,Maheswaran, P.,Leissing, T.,Aik, W.S.,McDonough, M.A.,Schofield, C.J. (deposition date: 2021-03-04, release date: 2021-10-13, Last modification date: 2024-01-31)

• Primary citation: Shishodia, S.,Demetriades, M.,Zhang, D.,Tam, N.Y.,Maheswaran, P.,Clunie-O'Connor, C.,Tumber, A.,Leung, I.K.H.,Ng, Y.M.,Leissing, T.M.,El-Sagheer, A.H.,Salah, E.,Brown, T.,Aik, W.S.,McDonough, M.A.,Schofield, C.J.; Structure-Based Design of Selective Fat Mass and Obesity Associated Protein (FTO) Inhibitors.; J.Med.Chem., 64:16609-16625, 2021; PubMed: 34762429; DOI: 10.1021/acs.jmedchem.1c01204

Experimental method

X-RAY DIFFRACTION (1.25 Å)