7N93
P70 S6K1 IN COMPLEX WITH MSC2363318A-1
Summary for 7N93
Entry DOI | 10.2210/pdb7n93/pdb |
Related | 7N91 |
Descriptor | Ribosomal protein S6 kinase beta-1, 4-({(1S)-2-(azetidin-1-yl)-1-[4-chloro-3-(trifluoromethyl)phenyl]ethyl}amino)quinazoline-8-carboxamide (3 entities in total) |
Functional Keywords | kinase domain, inhibitor, transferase, transferase-inhibitor complex, transferase/inhibitor |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 2 |
Total formula weight | 77992.23 |
Authors | Mochalkin, I. (deposition date: 2021-06-16, release date: 2022-07-06, Last modification date: 2023-10-18) |
Primary citation | DeSelm, L.,Huck, B.,Lan, R.,Neagu, C.,Potnick, J.,Xiao, Y.,Chen, X.,Jones, R.,Richardson, T.E.,Heasley, B.H.,Haxell, T.,Moore, J.,Tian, H.,Georgi, K.,Rohdich, F.,Sutton, A.,Johnson, T.,Mochalkin, I.,Jackson, J.,Lin, J.,Crowley, L.,Machl, A.,Clark, A.,Wilker, E.,Sherer, B.,Goutopoulos, A. Identification of Clinical Candidate M2698, a Dual p70S6K and Akt Inhibitor, for Treatment of PAM Pathway-Altered Cancers. J.Med.Chem., 64:14603-14619, 2021 Cited by PubMed: 34596404DOI: 10.1021/acs.jmedchem.1c01087 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.74 Å) |
Structure validation
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