7MPH
GRB2 SH2 Domain with Compound 7
Summary for 7MPH
Entry DOI | 10.2210/pdb7mph/pdb |
Descriptor | Growth factor receptor-bound protein 2, (4-{(10R,11E,14S,18S)-18-(2-amino-2-oxoethyl)-14-[(naphthalen-1-yl)methyl]-8,17,20-trioxo-7,16,19-triazaspiro[5.14]icos-11-en-10-yl}phenyl)acetic acid, 1,2-ETHANEDIOL, ... (5 entities in total) |
Functional Keywords | inhibitor, complex, growth factor receptor, ras-mapk signaling cascade, protein binding |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 6 |
Total formula weight | 71830.90 |
Authors | Sun, L.,Schonbrunn, E. (deposition date: 2021-05-04, release date: 2021-09-22, Last modification date: 2023-10-18) |
Primary citation | Xiao, T.,Sun, L.,Zhang, M.,Li, Z.,Haura, E.B.,Schonbrunn, E.,Ji, H. Synthesis and structural characterization of a monocarboxylic inhibitor for GRB2 SH2 domain. Bioorg.Med.Chem.Lett., 51:128354-128354, 2021 Cited by PubMed: 34506932DOI: 10.1016/j.bmcl.2021.128354 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2 Å) |
Structure validation
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