7MON
Structure of human RIPK3-MLKL complex
Summary for 7MON
Entry DOI | 10.2210/pdb7mon/pdb |
Descriptor | Mixed lineage kinase domain-like protein, Receptor-interacting serine/threonine-protein kinase 3, N-[4-({2-[(cyclopropanecarbonyl)amino]pyridin-4-yl}oxy)-3-fluorophenyl]-1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxamide, ... (4 entities in total) |
Functional Keywords | pseudokinase, kinase, complex, necroptosis, transferase |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 2 |
Total formula weight | 68806.46 |
Authors | Meng, Y.,Davies, K.A.,Czabotar, P.E.,Murphy, J.M. (deposition date: 2021-05-03, release date: 2021-11-17, Last modification date: 2023-10-18) |
Primary citation | Meng, Y.,Davies, K.A.,Fitzgibbon, C.,Young, S.N.,Garnish, S.E.,Horne, C.R.,Luo, C.,Garnier, J.M.,Liang, L.Y.,Cowan, A.D.,Samson, A.L.,Lessene, G.,Sandow, J.J.,Czabotar, P.E.,Murphy, J.M. Human RIPK3 maintains MLKL in an inactive conformation prior to cell death by necroptosis. Nat Commun, 12:6783-6783, 2021 Cited by PubMed: 34811356DOI: 10.1038/s41467-021-27032-x PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.23 Å) |
Structure validation
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