7M3G
Asymmetric Activation of the Calcium Sensing Receptor Homodimer
Summary for 7M3G
Entry DOI | 10.2210/pdb7m3g/pdb |
EMDB information | 23654 |
Descriptor | Extracellular calcium-sensing receptor, etelcalcetide, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (8 entities in total) |
Functional Keywords | gpcr, calcium sensing receptor, active state, positive allosteric modulator, family c gpcr, membrane protein |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 4 |
Total formula weight | 210058.86 |
Authors | Gao, Y.,Robertson, M.J.,Zhang, C.,Meyerowitz, J.G.,Panova, O.,Skiniotis, G. (deposition date: 2021-03-18, release date: 2021-06-30, Last modification date: 2021-07-21) |
Primary citation | Gao, Y.,Robertson, M.J.,Rahman, S.N.,Seven, A.B.,Zhang, C.,Meyerowitz, J.G.,Panova, O.,Hannan, F.M.,Thakker, R.V.,Brauner-Osborne, H.,Mathiesen, J.M.,Skiniotis, G. Asymmetric activation of the calcium-sensing receptor homodimer. Nature, 595:455-459, 2021 Cited by PubMed: 34194040DOI: 10.1038/s41586-021-03691-0 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (2.5 Å) |
Structure validation
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