7M05
CryoEM structure of PRMT5 bound to covalent PBM-site inhibitor BRD-6988
Summary for 7M05
Entry DOI | 10.2210/pdb7m05/pdb |
EMDB information | 23609 |
Descriptor | Protein arginine N-methyltransferase 5, Methylosome protein 50, 2-(5-chloro-6-oxopyridazin-1(6H)-yl)-N-(4-methyl-3-{[2-(pyridin-2-yl)ethyl]sulfamoyl}phenyl)acetamide (3 entities in total) |
Functional Keywords | methyltransferase, splicing, epigenetic, transferase-inhibitor complex, transferase/inhibitor |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 8 |
Total formula weight | 439807.00 |
Authors | McMillan, B.J.,McKinney, D.C.,Timm, D.E. (deposition date: 2021-03-10, release date: 2021-03-17, Last modification date: 2021-08-25) |
Primary citation | McKinney, D.C.,McMillan, B.J.,Ranaghan, M.J.,Moroco, J.A.,Brousseau, M.,Mullin-Bernstein, Z.,O'Keefe, M.,McCarren, P.,Mesleh, M.F.,Mulvaney, K.M.,Robinson, F.,Singh, R.,Bajrami, B.,Wagner, F.F.,Hilgraf, R.,Drysdale, M.J.,Campbell, A.J.,Skepner, A.,Timm, D.E.,Porter, D.,Kaushik, V.K.,Sellers, W.R.,Ianari, A. Discovery of a First-in-Class Inhibitor of the PRMT5-Substrate Adaptor Interaction. J.Med.Chem., 64:11148-11168, 2021 Cited by PubMed: 34342224DOI: 10.1021/acs.jmedchem.1c00507 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (2.39 Å) |
Structure validation
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