7M05
CryoEM structure of PRMT5 bound to covalent PBM-site inhibitor BRD-6988
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, C, E, G | Protein arginine N-methyltransferase 5 | polymer | 637 | 72766.7 | 4 | UniProt (O14744) Pfam (PF17285) Pfam (PF05185) Pfam (PF17286) In PDB | Homo sapiens (Human) | 72 kDa ICln-binding protein,Histone-arginine N-methyltransferase PRMT5,Jak-binding protein 1,Shk1 kinase-binding protein 1 homolog,SKB1Hs |
| 2 | B, D, F, H | Methylosome protein 50 | polymer | 342 | 36723.2 | 4 | UniProt (Q9BQA1) Pfam (PF00400) In PDB | Homo sapiens (Human) | MEP-50,Androgen receptor cofactor p44,WD repeat-containing protein 77,p44/Mep50 |
| 3 | A, C, E, G | 2-(5-chloro-6-oxopyridazin-1(6H)-yl)-N-(4-methyl-3-{[2-(pyridin-2-yl)ethyl]sulfamoyl}phenyl)acetamide | non-polymer | 461.9 | 4 | Chemie (YJG) |
Sequence modifications
B, D, F, H: 2 - 342 (UniProt: Q9BQA1)
| PDB | External Database | Details |
|---|---|---|
| Pro 1 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 8 |
| Total formula weight | 437959.3 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 1847.7 | |
| All* | Total formula weight | 439807.0 |
