7LQW

Cryo-EM structure of NTD-directed neutralizing antibody 2-17 Fab in complex with SARS-CoV-2 S2P spike

Summary for 7LQW

• Entry DOI: 10.2210/pdb7lqw/pdb
• EMDB information: 23489 23490
• Descriptor: 2-17 Heavy Chain, 2-17 Light Chain, Spike glycoprotein, ... (4 entities in total)
• Functional Keywords: covid, covid19, sars-cov2, prefusion, neutralizing, ntd, viral protein-immune system complex, viral protein/immune system
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 5
• Total formula weight: 485840.97

Authors

Gorman, J.,Rapp, M.,Kwong, P.D.,Shapiro, L. (deposition date: 2021-02-15, release date: 2021-03-24, Last modification date: 2021-05-26)

• Primary citation: Cerutti, G.,Guo, Y.,Zhou, T.,Gorman, J.,Lee, M.,Rapp, M.,Reddem, E.R.,Yu, J.,Bahna, F.,Bimela, J.,Huang, Y.,Katsamba, P.S.,Liu, L.,Nair, M.S.,Rawi, R.,Olia, A.S.,Wang, P.,Zhang, B.,Chuang, G.Y.,Ho, D.D.,Sheng, Z.,Kwong, P.D.,Shapiro, L.; Potent SARS-CoV-2 neutralizing antibodies directed against spike N-terminal domain target a single supersite.; Cell Host Microbe, 29:819-833.e7, 2021; PubMed: 33789084; DOI: 10.1016/j.chom.2021.03.005

Experimental method

ELECTRON MICROSCOPY (4.47 Å)