7LON
Ornithine Aminotransferase (OAT) cocrystallized with its inactivator - (1S,3S)-3-amino-4-(difluoromethylene)cyclohexene-1-carboxylic acid
Summary for 7LON
Entry DOI | 10.2210/pdb7lon/pdb |
Descriptor | Ornithine aminotransferase, mitochondrial, THREONINE, (1R,3S,4R)-3-[({3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4-yl}methyl)amino]-4-methylcyclohexane-1-carboxylic acid, ... (4 entities in total) |
Functional Keywords | ornithine aminotransferase, oat, aminotransferase, inactivator, inhibitor, transferase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 3 |
Total formula weight | 136103.38 |
Authors | Butrin, A.,Zhu, W.,Liu, D.,Silverman, R. (deposition date: 2021-02-10, release date: 2021-08-25, Last modification date: 2023-10-18) |
Primary citation | Zhu, W.,Doubleday, P.F.,Butrin, A.,Weerawarna, P.M.,Melani, R.D.,Catlin, D.S.,Dwight, T.A.,Liu, D.,Kelleher, N.L.,Silverman, R.B. Remarkable and Unexpected Mechanism for ( S )-3-Amino-4-(difluoromethylenyl)cyclohex-1-ene-1-carboxylic Acid as a Selective Inactivator of Human Ornithine Aminotransferase. J.Am.Chem.Soc., 143:8193-8207, 2021 Cited by PubMed: 34014654DOI: 10.1021/jacs.1c03572 PDB entries with the same primary citation |
Experimental method |
Structure validation
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