7LM2
HUMAN PI3KDELTA IN COMPLEX WITH COMPOUND 3C
Summary for 7LM2
Entry DOI | 10.2210/pdb7lm2/pdb |
Descriptor | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform, Phosphatidylinositol 3-kinase regulatory subunit alpha, cyclopropyl[(3S)-3-{[9-ethyl-8-(2-methylpyrimidin-5-yl)-9H-purin-6-yl]amino}pyrrolidin-1-yl]methanone, ... (6 entities in total) |
Functional Keywords | pi3kdelta kinase, transferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 2 |
Total formula weight | 138292.01 |
Authors | Lesburg, C.A.,Augustin, M. (deposition date: 2021-02-05, release date: 2021-04-21, Last modification date: 2024-04-03) |
Primary citation | Methot, J.L.,Zhou, H.,McGowan, M.A.,Anthony, N.J.,Christopher, M.,Garcia, Y.,Achab, A.,Lipford, K.,Trotter, B.W.,Altman, M.D.,Fradera, X.,Lesburg, C.A.,Li, C.,Alves, S.,Chappell, C.P.,Jain, R.,Mangado, R.,Pinheiro, E.,Williams, S.M.G.,Goldenblatt, P.,Hill, A.,Shaffer, L.,Chen, D.,Tong, V.,McLeod, R.L.,Lee, H.H.,Yu, H.,Shah, S.,Katz, J.D. Projected Dose Optimization of Amino- and Hydroxypyrrolidine Purine PI3K delta Immunomodulators. J.Med.Chem., 64:5137-5156, 2021 Cited by PubMed: 33797901DOI: 10.1021/acs.jmedchem.1c00237 PDB entries with the same primary citation |
Experimental method |
Structure validation
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