7LHZ

K. pneumoniae Topoisomerase IV (ParE-ParC) in complex with DNA and (3S)-10-[(3R)-3-(1-aminocyclopropyl)pyrrolidin-1-yl]-9-fluoro-3-methyl-5-oxo-2,3-dihydro-5H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxylic acid (compound 25)

Summary for 7LHZ

• Entry DOI: 10.2210/pdb7lhz/pdb
• Descriptor: DNA topoisomerase 4 subunit B, DNA topoisomerase 4 subunit A chimera, DNA (5'-D(P*TP*AP*CP*GP*TP*TP*GP*TP*AP*T)-3'), DNA (5'-D(*GP*AP*TP*CP*AP*TP*AP*CP*AP*AP*CP*GP*TP*AP*A)-3'), ... (7 entities in total)
• Functional Keywords: gyrase, dna topoisomerase, parc, pare, isomerase-dna-inhibitor complex, isomerase/dna/inhibitor
• Biological source: Klebsiella pneumoniae 342; More
• Total number of polymer chains: 12
• Total formula weight: 370442.11

Authors

Noeske, J.,Shu, W.,Bellamacina, C. (deposition date: 2021-01-26, release date: 2021-05-12, Last modification date: 2023-10-18)

• Primary citation: Lapointe, G.,Skepper, C.K.,Holder, L.M.,Armstrong, D.,Bellamacina, C.,Blais, J.,Bussiere, D.,Bian, J.,Cepura, C.,Chan, H.,Dean, C.R.,De Pascale, G.,Dhumale, B.,Fisher, L.M.,Fulsunder, M.,Kantariya, B.,Kim, J.,King, S.,Kossy, L.,Kulkarni, U.,Lakshman, J.,Leeds, J.A.,Ling, X.,Lvov, A.,Ma, S.,Malekar, S.,McKenney, D.,Mergo, W.,Metzger, L.,Mhaske, K.,Moser, H.E.,Mostafavi, M.,Namballa, S.,Noeske, J.,Osborne, C.,Patel, A.,Patel, D.,Patel, T.,Piechon, P.,Polyakov, V.,Prajapati, K.,Prosen, K.R.,Reck, F.,Richie, D.L.,Sanderson, M.R.,Satasia, S.,Savani, B.,Selvarajah, J.,Sethuraman, V.,Shu, W.,Tashiro, K.,Thompson, K.V.,Vaarla, K.,Vala, L.,Veselkov, D.A.,Vo, J.,Vora, B.,Wagner, T.,Wedel, L.,Williams, S.L.,Yendluri, S.,Yue, Q.,Yifru, A.,Zhang, Y.,Rivkin, A.; Discovery and Optimization of DNA Gyrase and Topoisomerase IV Inhibitors with Potent Activity against Fluoroquinolone-Resistant Gram-Positive Bacteria.; J.Med.Chem., 64:6329-6357, 2021; PubMed: 33929852; DOI: 10.1021/acs.jmedchem.1c00375

Experimental method

X-RAY DIFFRACTION (3.3 Å)