7LHZ
K. pneumoniae Topoisomerase IV (ParE-ParC) in complex with DNA and (3S)-10-[(3R)-3-(1-aminocyclopropyl)pyrrolidin-1-yl]-9-fluoro-3-methyl-5-oxo-2,3-dihydro-5H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxylic acid (compound 25)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (C, D, A, B) | DNA topoisomerase 4 subunit B, DNA topoisomerase 4 subunit A chimera | polymer | 743 | 84199.5 | 4 | UniProt (A0A377Y395) UniProt (A0A486EJ79) Pfam (PF01751) Pfam (PF00986) Pfam (PF00521) UniProt (by SIFTS) (B5XU53) UniProt (by SIFTS) (B5XU60) | Klebsiella pneumoniae 342 | Topoisomerase IV subunit B,Topoisomerase IV subunit A |
| 2 | E, H, J, L (P, J, H, E) | DNA (5'-D(P*TP*AP*CP*GP*TP*TP*GP*TP*AP*T)-3') | polymer | 11 | 3354.2 | 4 | Klebsiella pneumoniae 342 | ||
| 3 | F, G, I, K (K, I, G, F) | DNA (5'-D(*GP*AP*TP*CP*AP*TP*AP*CP*AP*AP*CP*GP*TP*AP*A)-3') | polymer | 15 | 4586.0 | 4 | Klebsiella pneumoniae 342 | ||
| 4 | M, P (C, A) | (4S)-2-METHYL-2,4-PENTANEDIOL | non-polymer | 118.2 | 2 | Chemie (MPD) | |||
| 5 | N, O, Q, R (C, D, A, B) | MAGNESIUM ION | non-polymer | 24.3 | 4 | Chemie (MG) | |||
| 6 | S, T, U, V (K, I, G, F) | (3S)-10-[(3R)-3-(1-aminocyclopropyl)pyrrolidin-1-yl]-9-fluoro-3-methyl-5-oxo-2,3-dihydro-5H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxylic acid | non-polymer | 387.4 | 4 | Chemie (Y21) | |||
| 7 | W, X, Y (C, A, P) | water | water | 18.0 | 4 | Chemie (HOH) |
Sequence modifications
C, D, A, B: 390 - 998 (UniProt: A0A377Y395)
C, D, A, B: 1001 - 1490 (UniProt: A0A486EJ79)
| PDB | External Database | Details |
|---|---|---|
| Met 389 | - | initiating methionine |
| Glu 999 | - | linker |
| Phe 1000 | - | linker |
| PDB | External Database | Details |
|---|---|---|
| Thr 1255 | Ser 255 | conflict |
| Leu 1491 | - | expression tag |
| Glu 1492 | - | expression tag |
| His 1493 | - | expression tag |
| His 1494 | - | expression tag |
| His 1495 | - | expression tag |
| His 1496 | - | expression tag |
| His 1497 | - | expression tag |
| His 1498 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 12 |
| Total formula weight | 368558.9 | |
| Non-Polymers* | Number of molecules | 10 |
| Total formula weight | 1883.2 | |
| All* | Total formula weight | 370442.1 |
