7LFR
Crystal structure of the epidermal growth factor receptor extracellular region with R84K mutation in complex with epiregulin crystallized with spermine
Summary for 7LFR
Entry DOI | 10.2210/pdb7lfr/pdb |
Related | 7LEN |
Descriptor | Epidermal growth factor receptor, Proepiregulin, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (6 entities in total) |
Functional Keywords | receptor, epiregulin, glioblastoma, cancer, mutation, extracellular, asymmetric, dimer, erbb1, egfr, signaling protein |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 4 |
Total formula weight | 124597.39 |
Authors | Hu, C.,Leche II, C.A.,Stayrook, S.E.,Ferguson, K.M.,Lemmon, M.A. (deposition date: 2021-01-18, release date: 2021-11-17, Last modification date: 2023-10-18) |
Primary citation | Hu, C.,Leche 2nd, C.A.,Kiyatkin, A.,Yu, Z.,Stayrook, S.E.,Ferguson, K.M.,Lemmon, M.A. Glioblastoma mutations alter EGFR dimer structure to prevent ligand bias. Nature, 602:518-522, 2022 Cited by PubMed: 35140400DOI: 10.1038/s41586-021-04393-3 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.2 Å) |
Structure validation
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