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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

7LFR

Crystal structure of the epidermal growth factor receptor extracellular region with R84K mutation in complex with epiregulin crystallized with spermine

Functional Information from PROSITE/UniProt
site_idPS00022
Number of Residues12
DetailsEGF_1 EGF-like domain signature 1. CrCevGytGVrC
ChainResidueDetails
CCYS30-CYS41
site_idPS01186
Number of Residues12
DetailsEGF_2 EGF-like domain signature 2. CrCevGYtgvr....C
ChainResidueDetails
CCYS30-CYS41
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues450
DetailsRepeat: {"description":"Approximate"}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues2
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"21487020","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues2
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) (complex) asparagine; atypical; partial","featureId":"CAR_000227","evidences":[{"source":"PubMed","id":"10731668","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"12297049","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"12297050","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"12731890","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16083266","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20837704","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1IVO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1MOX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3NJP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3QWQ","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues2
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine; atypical","evidences":[{"source":"PubMed","id":"20837704","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3NJP","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues2
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"12731890","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16083266","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8962717","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues2
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"12297050","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"12731890","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16083266","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20837704","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8962717","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1IVO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3NJP","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues2
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"12297049","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"12297050","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"12731890","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16083266","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20837704","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1IVO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1MOX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3NJP","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI8
Number of Residues2
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"10731668","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"12297049","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"12297050","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"12620237","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"12731890","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16083266","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19159218","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20837704","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1IVO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1MOX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1NQL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1YY9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3B2U","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3B2V","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3NJP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3P0Y","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3QWQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4KRL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4KRM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4KRO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4KRP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4UIP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4UV7","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI9
Number of Residues2
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"10731668","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"12297050","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"12620237","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"12731890","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16083266","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20837704","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1IVO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1NQL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1YY9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3B2U","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3NJP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3QWQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4KRL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4KRM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4KRO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4KRP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4UV7","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI10
Number of Residues2
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"12731890","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16083266","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19159218","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8962717","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1YY9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3B2U","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3B2V","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3P0Y","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3QWQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4KRO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4KRP","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI11
Number of Residues2
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"12297050","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"12620237","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"12731890","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16083266","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20837704","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8962717","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1IVO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1NQL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1YY9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3B2U","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3B2V","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3NJP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3P0Y","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3QWQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4KRL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4KRM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4KRO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4KRP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4UIP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4UV7","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI12
Number of Residues80
DetailsDomain: {"description":"EGF-like","evidences":[{"source":"PROSITE-ProRule","id":"PRU00076","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

246031

PDB entries from 2025-12-10

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