7LFR
Crystal structure of the epidermal growth factor receptor extracellular region with R84K mutation in complex with epiregulin crystallized with spermine
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Epidermal growth factor receptor | polymer | 502 | 55803.5 | 2 | UniProt (P00533) Pfam (PF01030) Pfam (PF00757) | Homo sapiens (Human) | Proto-oncogene c-ErbB-1,Receptor tyrosine-protein kinase erbB-1 |
| 2 | C, D (C, D) | Proepiregulin | polymer | 48 | 5480.3 | 2 | UniProt (O14944) | Homo sapiens (Human) | |
| 3 | E (F) | beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 383.3 | 1 | In PDB GlyTouCan (G90333CG) | |||
| 4 | F, H, I, J, K (A, B) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 5 | Chemie (NAG) | |||
| 5 | G, M (A, B) | alpha-D-mannopyranose | non-polymer | 180.2 | 2 | Chemie (MAN) | |||
| 6 | L (B) | beta-D-mannopyranose | non-polymer | 180.2 | 1 | Chemie (BMA) |
Sequence modifications
A, B: 1 - 501 (UniProt: P00533)
| PDB | External Database | Details |
|---|---|---|
| Lys 84 | Arg 108 | engineered mutation |
| His 502 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 122567.5 | |
| Branched | Number of molecules | 1 |
| Total formula weight | 383.3 | |
| Non-Polymers* | Number of molecules | 8 |
| Total formula weight | 1646.5 | |
| All* | Total formula weight | 124597.4 |
