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7LFR

Crystal structure of the epidermal growth factor receptor extracellular region with R84K mutation in complex with epiregulin crystallized with spermine

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A, BEpidermal growth factor receptorpolymer50255803.52UniProt (P00533)
Pfam (PF01030)
Pfam (PF00757)
In PDB
Homo sapiens (Human)Proto-oncogene c-ErbB-1,Receptor tyrosine-protein kinase erbB-1
2C, DProepiregulinpolymer485480.32UniProt (O14944)
In PDB
Homo sapiens (Human)
3Fbeta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranosebranched383.31In PDB
GlyTouCan (G90333CG)
4A, B2-acetamido-2-deoxy-beta-D-glucopyranosenon-polymer221.25Chemie (NAG)
5A, Balpha-D-mannopyranosenon-polymer180.22Chemie (MAN)
6Bbeta-D-mannopyranosenon-polymer180.21Chemie (BMA)
Sequence modifications
A, B: 1 - 501 (UniProt: P00533)
PDBExternal DatabaseDetails
Lys 84Arg 108engineered mutation
His 502-expression tag
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains4
Total formula weight122567.5
BranchedNumber of molecules1
Total formula weight383.3
Non-Polymers*Number of molecules8
Total formula weight1646.5
All*Total formula weight124597.4
*Water molecules are not included.

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PDB entries from 2024-06-12

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