7L8V

NMR Structure of half-calcified calmodulin mutant (CaMEF12) bound to the IQ-motif of CaV1.2

Summary for 7L8V

• Entry DOI: 10.2210/pdb7l8v/pdb
• NMR Information: BMRB: 27692
• Descriptor: Calmodulin-1, Voltage-dependent L-type calcium channel subunit alpha-1C, CALCIUM ION (3 entities in total)
• Functional Keywords: cav1.2, l-type channel, ef-hand, metal binding protein
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 2
• Total formula weight: 19344.85

Authors

Ames, J.B. (deposition date: 2021-01-01, release date: 2022-07-06, Last modification date: 2024-01-17)

• Primary citation: Bartels, P.,Salveson, I.,Coleman, A.M.,Anderson, D.E.,Jeng, G.,Estrada-Tobar, Z.M.,Man, K.N.M.,Yu, Q.,Kuzmenkina, E.,Nieves-Cintron, M.,Navedo, M.F.,Horne, M.C.,Hell, J.W.,Ames, J.B.; Half-calcified calmodulin promotes basal activity and inactivation of the L-type calcium channel Ca V 1.2.; J.Biol.Chem., 298:102701-102701, 2022; PubMed: 36395884; DOI: 10.1016/j.jbc.2022.102701

Experimental method

SOLUTION NMR