7L8V

NMR Structure of half-calcified calmodulin mutant (CaMEF12) bound to the IQ-motif of CaV1.2

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Calmodulin-1	polymer	149	16587.5	1	UniProt (P0DP23) Pfam (PF13499) In PDB	Homo sapiens (Human)
2	C	Voltage-dependent L-type calcium channel subunit alpha-1C	polymer	21	2677.2	1	UniProt (Q13936) In PDB	Homo sapiens (Human)	Calcium channel,L type,alpha-1 polypeptide,isoform 1,cardiac muscle,Voltage-gated calcium channel subunit alpha Cav1.2
3	A	CALCIUM ION	non-polymer		40.1	2	Chemie (CA)

Sequence modifications

A: 1 - 149 (UniProt: P0DP23)

PDB	External Database	Details
Ala 21	Asp 21	engineered mutation
Ala 23	Asp 23	engineered mutation
Ala 25	Asp 25	engineered mutation
Gln 32	Glu 32	engineered mutation
Ala 57	Asp 57	engineered mutation
Ala 59	Asp 59	engineered mutation
Ala 61	Asn 61	engineered mutation
Gln 68	Glu 68	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	19264.7
Non-Polymers*	Number of molecules	2
	Total formula weight	80.2
All*	Total formula weight	19344.8

*Water molecules are not included.