7L8V
NMR Structure of half-calcified calmodulin mutant (CaMEF12) bound to the IQ-motif of CaV1.2
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Calmodulin-1 | polymer | 149 | 16587.5 | 1 | UniProt (P0DP23) Pfam (PF13499) | Homo sapiens (Human) | |
| 2 | B (C) | Voltage-dependent L-type calcium channel subunit alpha-1C | polymer | 21 | 2677.2 | 1 | UniProt (Q13936) | Homo sapiens (Human) | Calcium channel,L type,alpha-1 polypeptide,isoform 1,cardiac muscle,Voltage-gated calcium channel subunit alpha Cav1.2 |
| 3 | C, D (A) | CALCIUM ION | non-polymer | 40.1 | 2 | Chemie (CA) |
Sequence modifications
A: 1 - 149 (UniProt: P0DP23)
| PDB | External Database | Details |
|---|---|---|
| Ala 21 | Asp 21 | engineered mutation |
| Ala 23 | Asp 23 | engineered mutation |
| Ala 25 | Asp 25 | engineered mutation |
| Gln 32 | Glu 32 | engineered mutation |
| Ala 57 | Asp 57 | engineered mutation |
| Ala 59 | Asp 59 | engineered mutation |
| Ala 61 | Asn 61 | engineered mutation |
| Gln 68 | Glu 68 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 19264.7 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 80.2 | |
| All* | Total formula weight | 19344.8 |
