7K6A

Crystal Structure of Dihydrofolate reductase (DHFR) from Mycobacterium ulcerans Agy99 in complex with NADP and inhibitor SDDC-0001575

Summary for 7K6A

• Entry DOI: 10.2210/pdb7k6a/pdb
• Descriptor: Dihydrofolate reductase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 6-ethyl-5-[3-({3-[4-(trifluoromethyl)piperidin-1-yl]pyridin-2-yl}oxy)propoxy]pyrimidine-2,4-diamine, ... (6 entities in total)
• Functional Keywords: ssgcid, sddc, inhibitor, structural genomics, seattle structural genomics center for infectious disease, oxidoreductase, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor
• Biological source: Mycobacterium ulcerans (strain Agy99)
• Total number of polymer chains: 1
• Total formula weight: 20457.21

Authors

Seattle Structural Genomics Center for Infectious Disease (SSGCID) (deposition date: 2020-09-19, release date: 2021-03-17, Last modification date: 2023-10-18)

• Primary citation: Abendroth, J.,Dranow, D.M.,Santhakumar, V.,Walpole, C.,Lorimer, D.D.,Horanyi, P.S.,Edwards, T.E.; Crystal Structure of Dihydrofolate reductase (DHFR) from Mycobacterium ulcerans Agy99 in complex with NADP and inhibitor SDDC-0001575; to be published,

Experimental method

X-RAY DIFFRACTION (1.6 Å)