7K15
Crystal structure of the Human Leukotriene B4 Receptor 1 in Complex with Selective Antagonist MK-D-046
Summary for 7K15
Entry DOI | 10.2210/pdb7k15/pdb |
Descriptor | Leukotriene B4 receptor 1,Flavodoxin,Leukotriene B4 receptor 1, N-(tert-butylsulfonyl)-4-fluoro-2-{(3S,4R)-4-hydroxy-3-[(pyridin-2-yl)methyl]-3,4-dihydro-2H-1-benzopyran-7-yl}benzamide, SODIUM ION, ... (10 entities in total) |
Functional Keywords | human leukotriene b4 receptor 1, hblt1, blt1, bltr1, ltb4, ltb4r, lt4r1, ltb4r1, mk-d-046, selective antagonist, inflammation, inflammatory disease, type 2 diabetes, g protein-coupled receptor, gpcr, flavodoxin fusion, membrane protein, lcp |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 1 |
Total formula weight | 56140.17 |
Authors | Michaelian, N.,Han, G.W.,Cherezov, V. (deposition date: 2020-09-07, release date: 2021-02-17, Last modification date: 2024-10-16) |
Primary citation | Michaelian, N.,Sadybekov, A.,Besserer-Offroy, E.,Han, G.W.,Krishnamurthy, H.,Zamlynny, B.A.,Fradera, X.,Siliphaivanh, P.,Presland, J.,Spencer, K.B.,Soisson, S.M.,Popov, P.,Sarret, P.,Katritch, V.,Cherezov, V. Structural insights on ligand recognition at the human leukotriene B4 receptor 1. Nat Commun, 12:2971-2971, 2021 Cited by PubMed: 34016973DOI: 10.1038/s41467-021-23149-1 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.88 Å) |
Structure validation
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