7JFR
Auristatin bound to tubulin
Summary for 7JFR
Entry DOI | 10.2210/pdb7jfr/pdb |
Related PRD ID | PRD_002435 |
Descriptor | Tubulin alpha-1B chain, PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER, Tubulin beta-2B chain, ... (11 entities in total) |
Functional Keywords | auristatin, tubulin, antimitotic, cell cycle |
Biological source | Rattus norvegicus (Rat) More |
Total number of polymer chains | 7 |
Total formula weight | 261237.38 |
Authors | Moquist, P.N.,Waight, A. (deposition date: 2020-07-17, release date: 2020-09-16, Last modification date: 2023-11-15) |
Primary citation | Moquist, P.N.,Bovee, T.D.,Waight, A.B.,Mitchell, J.A.,Miyamoto, J.B.,Mason, M.L.,Emmerton, K.K.,Stevens, N.,Balasubramanian, C.,Simmons, J.K.,Lyon, R.P.,Senter, P.D.,Doronina, S.O. Novel Auristatins with High Bystander and Cytotoxic Activities in Drug Efflux-positive Tumor Models. Mol.Cancer Ther., 20:320-328, 2021 Cited by PubMed: 33288628DOI: 10.1158/1535-7163.MCT-20-0618 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.35 Å) |
Structure validation
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