7F8G
Structure-activity relationship studies of allosteric inhibitors of EYA2 tyrosine phosphatase
Summary for 7F8G
Entry DOI | 10.2210/pdb7f8g/pdb |
Descriptor | Eyes absent homolog 2, 3-phenoxy-~{N}-[(~{E})-(5-pyrimidin-2-ylsulfanylfuran-2-yl)methylideneamino]benzamide (2 entities in total) |
Functional Keywords | eya2, eyes absent protein, phosphatase, transcription coactivator, transcription |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 2 |
Total formula weight | 66885.60 |
Authors | Anantharajan, J.,Baburajendran, N. (deposition date: 2021-07-02, release date: 2021-12-29, Last modification date: 2023-11-29) |
Primary citation | Anantharajan, J.,Baburajendran, N.,Lin, G.,Loh, Y.Y.,Xu, W.,Ahmad, N.H.B.,Liu, S.,Jansson, A.E.,Kuan, J.W.L.,Ng, E.Y.,Yeo, Y.K.,Hung, A.W.,Joy, J.,Hill, J.,Ford, H.L.,Zhao, R.,Keller, T.H.,Kang, C. Structure-activity relationship studies of allosteric inhibitors of EYA2 tyrosine phosphatase. Protein Sci., 31:422-431, 2022 Cited by PubMed: 34761455DOI: 10.1002/pro.4234 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.491 Å) |
Structure validation
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