7F0I
phosphodiesterase-9A in complex with inhibitor 4b
Summary for 7F0I
Entry DOI | 10.2210/pdb7f0i/pdb |
Descriptor | Isoform PDE9A2 of High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A, ZINC ION, MAGNESIUM ION, ... (5 entities in total) |
Functional Keywords | hydrolase-inhibitor complex, hydrolase/inhibitor |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 2 |
Total formula weight | 124534.46 |
Authors | Wu, Y.,Huang, Y.Y.,Luo, H.B. (deposition date: 2021-06-04, release date: 2022-04-13, Last modification date: 2023-11-29) |
Primary citation | Wu, Y.,Wang, Q.,Jiang, M.Y.,Huang, Y.Y.,Zhu, Z.,Han, C.,Tian, Y.J.,Zhang, B.,Luo, H.B. Discovery of Potent Phosphodiesterase-9 Inhibitors for the Treatment of Hepatic Fibrosis J.Med.Chem., 64:9537-9549, 2021 Cited by DOI: 10.1021/acs.jmedchem.1c00862PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.70000890032 Å) |
Structure validation
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