7F0I
phosphodiesterase-9A in complex with inhibitor 4b
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004114 | molecular_function | 3',5'-cyclic-nucleotide phosphodiesterase activity |
| A | 0004115 | molecular_function | 3',5'-cyclic-AMP phosphodiesterase activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005783 | cellular_component | endoplasmic reticulum |
| A | 0005794 | cellular_component | Golgi apparatus |
| A | 0005829 | cellular_component | cytosol |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0007165 | biological_process | signal transduction |
| A | 0008081 | molecular_function | phosphoric diester hydrolase activity |
| A | 0010613 | biological_process | positive regulation of cardiac muscle hypertrophy |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0032587 | cellular_component | ruffle membrane |
| A | 0042383 | cellular_component | sarcolemma |
| A | 0043204 | cellular_component | perikaryon |
| A | 0046068 | biological_process | cGMP metabolic process |
| A | 0046069 | biological_process | cGMP catabolic process |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0047555 | molecular_function | 3',5'-cyclic-GMP phosphodiesterase activity |
| A | 0048471 | cellular_component | perinuclear region of cytoplasm |
| A | 0141162 | biological_process | negative regulation of cAMP/PKA signal transduction |
| A | 1900273 | biological_process | positive regulation of long-term synaptic potentiation |
| A | 2000178 | biological_process | negative regulation of neural precursor cell proliferation |
| B | 0004114 | molecular_function | 3',5'-cyclic-nucleotide phosphodiesterase activity |
| B | 0004115 | molecular_function | 3',5'-cyclic-AMP phosphodiesterase activity |
| B | 0005515 | molecular_function | protein binding |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005783 | cellular_component | endoplasmic reticulum |
| B | 0005794 | cellular_component | Golgi apparatus |
| B | 0005829 | cellular_component | cytosol |
| B | 0005886 | cellular_component | plasma membrane |
| B | 0007165 | biological_process | signal transduction |
| B | 0008081 | molecular_function | phosphoric diester hydrolase activity |
| B | 0010613 | biological_process | positive regulation of cardiac muscle hypertrophy |
| B | 0016787 | molecular_function | hydrolase activity |
| B | 0032587 | cellular_component | ruffle membrane |
| B | 0042383 | cellular_component | sarcolemma |
| B | 0043204 | cellular_component | perikaryon |
| B | 0046068 | biological_process | cGMP metabolic process |
| B | 0046069 | biological_process | cGMP catabolic process |
| B | 0046872 | molecular_function | metal ion binding |
| B | 0047555 | molecular_function | 3',5'-cyclic-GMP phosphodiesterase activity |
| B | 0048471 | cellular_component | perinuclear region of cytoplasm |
| B | 0141162 | biological_process | negative regulation of cAMP/PKA signal transduction |
| B | 1900273 | biological_process | positive regulation of long-term synaptic potentiation |
| B | 2000178 | biological_process | negative regulation of neural precursor cell proliferation |
Functional Information from PROSITE/UniProt
| site_id | PS00126 |
| Number of Residues | 12 |
| Details | PDEASE_I_1 3'5'-cyclic nucleotide phosphodiesterase domain signature. HDLdHpGynNtY |
| Chain | Residue | Details |
| A | HIS292-TYR303 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | Active site: {"description":"Proton donor","evidences":[{"source":"PubMed","id":"18757755","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 12 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"18757755","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 8 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"18757755","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19919087","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20121115","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21483814","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22985069","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23025719","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2HD1","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2YY2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3DYN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3JSI","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3JSW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3K3E","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3K3H","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3N3Z","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4E90","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4G2J","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4G2L","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4GH6","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"Q8QZV1","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
