7E4R
Crystal structure of tubulin in complex with D-DM1-SMe
Summary for 7E4R
Entry DOI | 10.2210/pdb7e4r/pdb |
Descriptor | Tubulin alpha-1B chain, (10E,12E)-86-chloro-14-hydroxy-85,14-dimethoxy-33,2,7,10-tetramethyl-12,6-dioxo-7-aza-1(6,4)-oxazinana-3(2,3)-oxirana-8(1,3)-benzenacyclotetradecaphane-10,12-dien-4-yl N-methyl-N-(3-(methylsulfinothioyl)propanoyl)-D-alaninate, PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER, ... (12 entities in total) |
Functional Keywords | microtubule assembly inhibitors, structural protein-inhibitor complex, structural protein/inhibitor |
Biological source | Bos taurus (Bovine) More |
Total number of polymer chains | 6 |
Total formula weight | 258498.85 |
Authors | |
Primary citation | Li, W.,Huang, M.,Li, Y.,Xia, A.,Tan, L.,Zhang, Z.,Wang, Y.,Yang, J. C3 ester side chain plays a pivotal role in the antitumor activity of Maytansinoids. Biochem.Biophys.Res.Commun., 566:197-203, 2021 Cited by PubMed: 34144258DOI: 10.1016/j.bbrc.2021.05.071 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.597 Å) |
Structure validation
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