7DV6
Discovery of Functionally Selective Transforming Growth Factor beta Type II Receptor (TGF-beta RII) Inhibitors as Anti-Fibrosis Agents
Summary for 7DV6
Entry DOI | 10.2210/pdb7dv6/pdb |
Descriptor | TGF-beta receptor type-2, 5-[(3S)-5,5-dimethyloxolan-3-yl]-6-methoxy-3-(2-methoxypyridin-4-yl)pyrazolo[1,5-a]pyrimidine (3 entities in total) |
Functional Keywords | inhibitor, complex, immune system |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 37142.11 |
Authors | Nishihata, J.,Nomura, A.,Miwa, S.,Doi, S.,Adachi, T. (deposition date: 2021-01-12, release date: 2021-06-16, Last modification date: 2023-11-29) |
Primary citation | Miwa, S.,Yokota, M.,Ueyama, Y.,Maeda, K.,Ogoshi, Y.,Seki, N.,Ogawa, N.,Nishihata, J.,Nomura, A.,Adachi, T.,Kitao, Y.,Nozawa, K.,Ishikawa, T.,Ukaji, Y.,Shiozaki, M. Discovery of Selective Transforming Growth Factor beta Type II Receptor Inhibitors as Antifibrosis Agents. Acs Med.Chem.Lett., 12:745-751, 2021 Cited by PubMed: 34055221DOI: 10.1021/acsmedchemlett.0c00679 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.39 Å) |
Structure validation
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