7DAF
IXA in complex with tubulin
Summary for 7DAF
Entry DOI | 10.2210/pdb7daf/pdb |
Descriptor | Tubulin alpha-1B chain, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, (1~{S},3~{S},7~{S},10~{R},11~{S},12~{S},16~{R})-8,8,10,12,16-pentamethyl-3-[(~{E})-1-(2-methyl-1,3-thiazol-4-yl)prop-1-en-2-yl]-7,11-bis(oxidanyl)-17-oxa-4-azabicyclo[14.1.0]heptadecane-5,9-dione, ... (13 entities in total) |
Functional Keywords | tubulin, protein-drug complex, cell cycle |
Biological source | Mus musculus (Mouse) More |
Total number of polymer chains | 6 |
Total formula weight | 265308.06 |
Authors | |
Primary citation | Xiao, Q.,Xue, T.,Shuai, W.,Wu, C.,Zhang, Z.,Zhang, T.,Zeng, S.,Sun, B.,Wang, Y. High-resolution X-ray structure of three microtubule-stabilizing agents in complex with tubulin provide a rationale for drug design. Biochem.Biophys.Res.Commun., 534:330-336, 2021 Cited by PubMed: 33272565DOI: 10.1016/j.bbrc.2020.11.082 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.4 Å) |
Structure validation
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