7C7O

Crystal structure of E.coli DNA gyrase B in complex with 6-fluoro-8-(methylamino)-2-oxo-1,2-dihydroquinoline derivative

Summary for 7C7O

Entry DOI	10.2210/pdb7c7o/pdb
Descriptor	DNA gyrase subunit B, 4-[[4-(3-azanylpropylamino)-6-fluoranyl-8-(methylamino)-2-oxidanylidene-1~{H}-quinolin-3-yl]carbonylamino]benzoic acid (3 entities in total)
Functional Keywords	inhibitor, complex, topoisomerase, escherichia coli, isomerase
Biological source	Escherichia coli
Total number of polymer chains	1
Total formula weight	24618.61
Authors	Kamitani, M.,Mima, M.,Takeuchi, T.,Ushiyama, F. (deposition date: 2020-05-26, release date: 2020-10-14, Last modification date: 2023-11-29)
Primary citation	Ushiyama, F.,Amada, H.,Mihara, Y.,Takeuchi, T.,Tanaka-Yamamoto, N.,Mima, M.,Kamitani, M.,Wada, R.,Tamura, Y.,Endo, M.,Masuko, A.,Takata, I.,Hitaka, K.,Sugiyama, H.,Ohtake, N. Lead optimization of 8-(methylamino)-2-oxo-1,2-dihydroquinolines as bacterial type II topoisomerase inhibitors. Bioorg.Med.Chem., 28:115776-115776, 2020 Cited by PubMed: 33032189 DOI: 10.1016/j.bmc.2020.115776 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.8 Å)

Structure validation