7C2Z
Bromodomain-containing 4 BD1 in complex with 3',4',7,8-Tetrahydroxyflavone
Summary for 7C2Z
Entry DOI | 10.2210/pdb7c2z/pdb |
Descriptor | Bromodomain-containing protein 4, 2-[3,4-bis(oxidanyl)phenyl]-7,8-bis(oxidanyl)chromen-4-one, FORMIC ACID, ... (4 entities in total) |
Functional Keywords | brd4, bd1, 3', 4', 7, 8- tetrahydroxyflavonoid, acute myeloid leukemia, c-myc, gene regulation |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 15344.56 |
Authors | |
Primary citation | Li, J.,Zou, W.,Yu, K.,Liu, B.,Liang, W.,Wang, L.,Lu, Y.,Jiang, Z.,Wang, A.,Zhu, J. Discovery of the natural product 3',4',7,8-tetrahydroxyflavone as a novel and potent selective BRD4 bromodomain 2 inhibitor. J Enzyme Inhib Med Chem, 36:903-913, 2021 Cited by PubMed: 33820450DOI: 10.1080/14756366.2021.1906663 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.3 Å) |
Structure validation
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