7BZJ
The Discovery of Benzhydrol-Oxaborole Hybrid Derivatives as Leucyl-tRNA Synthetase Inhibitors
Summary for 7BZJ
Entry DOI | 10.2210/pdb7bzj/pdb |
Descriptor | Leucine--tRNA ligase, [(1~{R},5~{R},6~{S},8~{R})-8-(6-aminopurin-9-yl)-4'-[(~{R})-oxidanyl-[4-(2-oxidanylidenepropylsulfanyl)phenyl]methyl]spiro[2,4,7-trioxa-3-boranuidabicyclo[3.3.0]octane-3,7'-7-boranuidabicyclo[4.3.0]nona-1(6),2,4-triene]-6-yl]methoxy-tris(oxidanyl)phosphanium (3 entities in total) |
Functional Keywords | leucyl-trna synthetase, pneumonia, rna binding protein-inhibitor complex, rna binding protein/inhibitor |
Biological source | Streptococcus pneumoniae (strain ATCC 700669 / Spain 23F-1) |
Total number of polymer chains | 1 |
Total formula weight | 21746.89 |
Authors | Liu, R.J.,Li, H.,Wang, E.D.,Zhou, H. (deposition date: 2020-04-28, release date: 2020-12-09, Last modification date: 2023-11-29) |
Primary citation | Hao, G.,Li, H.,Yang, F.,Dong, D.,Li, Z.,Ding, Y.,Pan, W.,Wang, E.,Liu, R.,Zhou, H. Discovery of benzhydrol-oxaborole derivatives as Streptococcus pneumoniae leucyl-tRNA synthetase inhibitors. Bioorg.Med.Chem., 29:115871-115871, 2021 Cited by PubMed: 33221064DOI: 10.1016/j.bmc.2020.115871 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2 Å) |
Structure validation
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